(2S)-2-methyl-5-oxohexanoic acid

Base Information

• Chemical Name: (2S)-2-methyl-5-oxohexanoic acid
• CAS No.: 54248-02-1
• Molecular Formula: C7H12O3
• Molecular Weight: 144.17
• Mol file: 54248-02-1.mol

Synonyms:

Chemical Property of (2S)-2-methyl-5-oxohexanoic acid

Chemical Property:

• Vapor Pressure: 0.00116mmHg at 25°C
• Boiling Point: 278.2°Cat760mmHg
• Flash Point: 136.3°C
• Density: 1.058g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-2-methyl-5-oxohexanoic acid

There total 5 articles about (2S)-2-methyl-5-oxohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

n-pentyl methyl ketone (110-43-0) + carbon monoxide (201230-82-2) → 2,5-dimethyladipic acid (4454-18-6) + α-methyl-δ-oxocaproic acid (54248-02-1) + 6-oxo-2-methyl-heptanoic acid (2570-68-5)

Guidance literature:

With hydrogen fluoride; antimony pentafluoride; at 20 ℃; for 3h; Product distribution; Mechanism; formation of oxo carboxylic acids; further alkyl methyl ketones;

DOI:10.1246/cl.1983.19

Reference yield:

formic acid (64-18-6) + 5-Hexen-2-one (109-49-9) → 6-oxoheptanoic acid (3128-07-2) + α-methyl-δ-oxocaproic acid (54248-02-1)

Guidance literature:

With carbon monoxide; palladium on activated charcoal; 1,4-di(diphenylphosphino)-butane; In 1,2-dimethoxyethane; at 150 ℃; for 24h; under 5168 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00069a045

Reference yield:

5-Hexen-2-one (109-49-9) + oxalic acid (144-62-7,97993-78-7) → 6-oxoheptanoic acid (3128-07-2) + α-methyl-δ-oxocaproic acid (54248-02-1)

Guidance literature:

With carbon monoxide; palladium on activated charcoal; 1,4-di(diphenylphosphino)-butane; In 1,2-dimethoxyethane; at 150 ℃; for 24h; under 30400 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00069a045

upstream raw materials:

formic acid

5-Hexen-2-one

n-pentyl methyl ketone

carbon monoxide