1-(2-Chloro-1,2-diphenylethenyl)-4-methoxybenzene

Base Information

Chemical Name:1-(2-Chloro-1,2-diphenylethenyl)-4-methoxybenzene
CAS No.:72474-42-1
Molecular Formula:C21H17ClO
Molecular Weight:320.818
Hs Code.:
DSSTox Substance ID:DTXSID70395637

Synonyms:1-(2-chloro-1,2-diphenylethenyl)-4-methoxybenzene;72474-42-1;SCHEMBL23358693;DTXSID70395637

Suppliers and Price of 1-(2-Chloro-1,2-diphenylethenyl)-4-methoxybenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-Chloro-1,2-diphenylethenyl)-4-methoxybenzene

Chemical Property:

XLogP3:6.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:320.0967929
Heavy Atom Count:23
Complexity:383

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3

Technology Process of 1-(2-Chloro-1,2-diphenylethenyl)-4-methoxybenzene

There total 13 articles about 1-(2-Chloro-1,2-diphenylethenyl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 501-65-5
diphenyl acetylene

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 72474-42-1
(Z)-(1-chloro-2-(4-methoxyphenyl)ethene-1,2-diyl)dibenzene

Guidance literature:: With N-chloro-succinimide; nickel(II) chloride hexahydrate; In toluene; at 20 - 60 ℃; for 1.5h; Inert atmosphere;

Reference yield: 54.0%

: 5720-07-0
4-methoxyphenylboronic acid

: C₁₄H₁₀BrCl

: 72474-42-1
(Z)-(1-chloro-2-(4-methoxyphenyl)ethene-1,2-diyl)dibenzene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydroxide; In tetrahydrofuran; methanol; at 110 ℃; for 12h; Schlenk technique;
DOI:10.1002/cjoc.202100472

Reference yield:

: 932-87-6
1-Bromo-2-phenylacetylene

: 72474-42-1
(Z)-(1-chloro-2-(4-methoxyphenyl)ethene-1,2-diyl)dibenzene

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide; N-chloro-succinimide / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube

2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere

3: potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique

With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;
DOI:10.1002/cjoc.202100472