Ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate

Base Information

Chemical Name:Ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate
CAS No.:72676-98-3
Molecular Formula:C14H18O6
Molecular Weight:282.293
Hs Code.:
DSSTox Substance ID:DTXSID001207356

Synonyms:Ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate;DTXSID001207356;72676-98-3

Suppliers and Price of Ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:282.11033829
Heavy Atom Count:20
Complexity:302

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)COC1=C(C=C(C=C1)C2OCCO2)OC

Technology Process of Ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate

There total 1 articles about Ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51264-70-1
ethyl 2-(4-formyl-2-methoxyphenoxy)acetate

: 107-21-1
ethylene glycol

: 72676-98-3
ethyl [4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 8h; Heating;
DOI:10.1021/jo035052w

Reference yield: 43.0%

: 123-11-5
4-methoxy-benzaldehyde

: 72676-98-3
ethyl [4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate

: (+/-)-(2R,3S)-ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]-3-hydroxy-3-(4-methoxyphenyl)propionate

: (+/-)-(2S,3S)-ethyl 2-[4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]-3-hydroxy-3-(4-methoxyphenyl)propionate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1h;
DOI:10.1021/jo035052w

Reference yield:

: 72676-98-3
ethyl [4-(1,3-dioxolan-2-yl)-2-methoxyphenoxy]acetate

: (+/-)-(1R,2R)-3-{4-[2',2'-dimethyl-1',3'-dioxan-4'-(4-methoxyphenyl)-5'-yloxy]-3-methoxyphenyl}-2-(4-methylphenoxy)-1,3-propanediol

Guidance literature:: Multi-step reaction with 6 steps

1: 43 percent / LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -78 °C

2: NaBH₄ / tetrahydrofuran; H₂O / 16 h / 20 °C

3: PPTS; H₂O / acetone / 4 h / Heating

4: 53 percent / TsOH; 4 Angstroem molecular sieves / 2 h

5: 73 percent / LDA / tetrahydrofuran; heptane; ethylbenzene / 0.67 h / -78 °C

6: NaBH₄ / tetrahydrofuran; H₂O / 24 h / 20 °C

With sodium tetrahydroborate; 4 A molecular sieve; water; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; water; acetone;
DOI:10.1021/jo035052w