2,6-Difluoro-4-morpholin-4-ylbenzonitrile

Base Information

• Chemical Name: 2,6-Difluoro-4-morpholin-4-ylbenzonitrile
• CAS No.: 840481-30-3
• Molecular Formula: C11H10F2N2O
• Molecular Weight: 224.21
• Hs Code.: 2934999090
• Mol file: 840481-30-3.mol

Synonyms:2,6-DIFLUORO-4-MORPHOLIN-4-YLBENZONITRILE;

Chemical Property of 2,6-Difluoro-4-morpholin-4-ylbenzonitrile

Chemical Property:

• PSA: 36.26000
• LogP: 1.73808

Purity/Quality:

99%, ^*data from raw suppliers

2,6-Difluoro-4-(morpholin-4-yl)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Difluoro-4-morpholin-4-ylbenzonitrile

There total 1 articles about 2,6-Difluoro-4-morpholin-4-ylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

morpholine (110-91-8,99108-56-2) + 2,4,6-trifluorobenzonitrile (96606-37-0,103498-69-7) → 2,6-difluoro-4-morpholin-4-yl-benzonitrile (840481-30-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In methanol; at 50 ℃; for 18h;

Reference yield: 90.0%

2,6-difluoro-4-morpholin-4-yl-benzonitrile (840481-30-3) → C11H12FN3O

Guidance literature:

With ammonia; In 1,4-dioxane; at 180 ℃; for 18h; under 30003 Torr;

Reference yield:

methanol (67-56-1) + 2,6-difluoro-4-morpholin-4-yl-benzonitrile (840481-30-3) + ethanol (64-17-5) + sodium ethanolate (141-52-6) → 2-fluoro-6-methoxy-4-morpholin-4-ylbenzonitrile + 2-fluoro-6-ethoxy-4-morpholin-4-ylbenzonitrile

Guidance literature:

at 0 - 60 ℃; for 5h;

upstream raw materials:

morpholine

2,4,6-trifluorobenzonitrile