Chemical Property of Carbimazole
Chemical Property:
- Vapor Pressure:0.038mmHg at 25°C
- Melting Point:124 °C
- Refractive Index:1.611
- Boiling Point:240.4 °C at 760 mmHg
- PKA:-1.70±0.20(Predicted)
- Flash Point:99.2 °C
- PSA：68.25000
- Density:1.31 g/cm3
- LogP:1.56070
- Storage Temp.:Refrigerator
- Sensitive.:Light Sensitive
- Solubility.:DMSO: soluble5mg/mL, clear (warmed)
- Water Solubility.:Soluble in water, ethanol, chloroform and acetone. Sightly soluble in water.
- XLogP3:0.7
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:2
- Exact Mass:186.04629874
- Heavy Atom Count:12
- Complexity:240
- Purity/Quality:
-
99% *data from raw suppliers
NUPL2 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Statements:
22-36-43
- Safety Statements:
22-36/37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCOC(=O)N1C=CN(C1=S)C
- Recent ClinicalTrials:Antithyroid Drug Treatment of Thyrotoxicosis in Young People
-
Uses
Carbimazole, a prodrug of Methimazole (M260300), is used in the treatment of hyperthyroidism. Thionamide antithyroid drug. Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate is used as thyroid inhibitor.
-
Therapeutic Function
Thyroid inhibitor
-
Clinical Use
Treatment of hyperthyroidism
-
Drug interactions
Potentially hazardous interactions with other drugs
None known
