10.1021/om1008132
The research investigates the synthesis and properties of ruthenium arene derivatives with chiral ferrocene-based P,N or P,O ligands. The study aims to explore the coordination behavior of these ligands with Ru(II)(arene) fragments and the transformation of chloro-alcohol complexes into hydrido-carbonyl complexes. Key chemicals used include ferrocene-based ligands (aminophosphines I-III and hydroxyphosphines IV-V), ruthenium precursors like [RuCl2(p-cymene)]2 and [RuCl2(benzene)(MeCN)], and NaBPh4. The researchers synthesized various complexes, such as [RuCl(arene)(P,N)]BPh4 and [RuH(arene)(P,CdO)]BPh4, and characterized them using techniques like NMR spectroscopy and X-ray diffraction. They found that the type of solvent, counterion, and presence of base significantly influence the formation of hydride complexes. The study concludes that the reactivity of alcohols at a metal center can be controlled by reaction conditions, and the complexes show potential for catalytic transfer hydrogenation of acetophenone, though with moderate enantioselectivity.
10.1016/j.tetlet.2014.02.118
The study presents an environmentally benign method for synthesizing isoxazolines and isoxazoles via a cycloaddition reaction mediated by potassium chloride (KCl) in water. The key chemicals involved are aldoximes, which are oxidized to nitrile oxides by hypochlorous acid generated in situ from KCl and the oxidant Oxone?. These nitrile oxides then undergo a 1,3-dipolar cycloaddition with alkenes or alkynes to form the desired isoxazolines and isoxazoles. The process is optimized to achieve high yields and involves using KCl as a mediator, Oxone? as the oxidant, and water as the solvent, offering a green and efficient alternative to traditional methods.
