Carbamic acid, [2-oxo-2-(2-propynylamino)ethyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [2-oxo-2-(2-propynylamino)ethyl]-, 1,1-dimethylethyl ester
• CAS No.: 847490-49-7
• Molecular Formula: C10H16N2O3
• Molecular Weight: 212.249
• Mol file: 847490-49-7.mol

Synonyms:Boc-N-propargylamino-glycine;tert-butyl 2-oxo-2-(prop-2-ynylamino)ethylcarbamate;tert-butyl(2-oxo-2-(prop-2-yn-1-ylamino)ethyl)carbamate;tert-butyl N-[2-oxo-2-(prop-2-ynylamino)ethyl]carbamate;((N-tert-butoxycarbonyl)glycyl)-propargylamine;Boc-glycine propargylamide;Prop-2-ynylcarbamoylmethyl-carbamic acid tert-butyl ester;

Chemical Property of Carbamic acid, [2-oxo-2-(2-propynylamino)ethyl]-, 1,1-dimethylethyl ester

Chemical Property:

• Melting Point: 100 - 101.5 °C (Petroleum ether)
• Boiling Point: 391.1±27.0 °C(Predicted)
• PSA: 67.43000
• Density: 1.084±0.06 g/cm3(Predicted)
• LogP: 1.04230

Purity/Quality:

99% ^*data from raw suppliers

tert-butylN-{[(prop-2-yn-1-yl)carbamoyl]methyl}carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [2-oxo-2-(2-propynylamino)ethyl]-, 1,1-dimethylethyl ester

There total 5 articles about Carbamic acid, [2-oxo-2-(2-propynylamino)ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

BOC-glycine (4530-20-5) + Propargylamine (2450-71-7) → tert-butyl (2-oxo-2-(prop-2-yn-1-ylamino)ethyl)carbamate (847490-49-7)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 6h; Inert atmosphere;

DOI:10.1021/jacs.7b11281

Reference yield: 90.0%

BOC-glycine (4530-20-5) + propargylamine (52324-04-6) → tert-butyl (2-oxo-2-(prop-2-yn-1-ylamino)ethyl)carbamate (847490-49-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1039/c2ob25774b

Reference yield: 79.0%

BOC-glycine (4530-20-5) + prop-2-yn-1-amine hydrochloride (15430-52-1) → tert-butyl (2-oxo-2-(prop-2-yn-1-ylamino)ethyl)carbamate (847490-49-7)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

DOI:10.1039/c4md00013g

upstream raw materials:

BOC-glycine

Propargylamine

propargylamine

prop-2-yn-1-amine hydrochloride

Downstream raw materials:

N-(2-oxo-2-(prop-2-yn-1-ylamino)ethyl)-2-(tritylthio)acetamide

N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-(tritylthio)acetamido)acetamide

N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-2-(2-mercapto acetamido)acetamide

C₃₂H₄₃F₃N₈O₅