5,8-Dioxa-2,11-diazadodecanoic acid, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 5,8-Dioxa-2,11-diazadodecanoic acid, 1,1-dimethylethyl ester
• CAS No.: 880359-74-0
• Molecular Formula: C12H26N2O4
• Molecular Weight: 262.349
• Mol file: 880359-74-0.mol

Synonyms:

Chemical Property of 5,8-Dioxa-2,11-diazadodecanoic acid, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,8-Dioxa-2,11-diazadodecanoic acid, 1,1-dimethylethyl ester

There total 1 articles about 5,8-Dioxa-2,11-diazadodecanoic acid, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) → tert-butyl N-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethyl]carbamate (880359-74-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 10 h / 90 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield: 69.0%

tert-butyl N-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethyl]carbamate (880359-74-0) + 2,4,6-Tris[o-(bromomethyl)phenyl]boroxine (7481-16-5) → C19H33BN2O6 (880359-75-1)

Guidance literature:

With potassium carbonate; In acetonitrile;

DOI:10.1016/j.bmcl.2005.11.062

Reference yield: 46.0%

tert-butyl N-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethyl]carbamate (880359-74-0) + formic acid (64-18-6) + tert-butyl N-(cyclopropylmethyl)-N-[4-[4-[[3-(difluoromethyl)-1-(4-formylcyclohexyl)pyrazol-4-yl]carbamoyl]oxazol-2-yl]-2-pyridyl]carbamate → tert-butyl N-[4-[4-[[1-[4-[[(2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethyl)methylamino]methyl]cyclohexyl]-3-(difluoromethyl)pyrazol-4-yl]carbamoyl]oxazol-2-yl]-2-pyridyl]-N-(cyclopropylmethyl)carbamate

Guidance literature:

tert-butyl N-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethyl]carbamate; tert-butyl N-(cyclopropylmethyl)-N-[4-[4-[[3-(difluoromethyl)-1-(4-formylcyclohexyl)pyrazol-4-yl]carbamoyl]oxazol-2-yl]-2-pyridyl]carbamate; With acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h; pH=5 - 6; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 10 ℃; for 2h; Inert atmosphere;

formic acid;

upstream raw materials:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

Downstream raw materials:

C₁₉H₃₃BN₂O₆

C₁₄H₂₅BN₂O₄

C₆₆H₁₀₃B₃N₈O₁₈