Benzeneacetic acid,R-(1-phenylethylidene)-

Base Information

• Chemical Name: Benzeneacetic acid,R-(1-phenylethylidene)-
• CAS No.: 34317-82-3
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.286
• Mol file: 34317-82-3.mol

Synonyms:

Chemical Property of Benzeneacetic acid,R-(1-phenylethylidene)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid,R-(1-phenylethylidene)-

There total 12 articles about Benzeneacetic acid,R-(1-phenylethylidene)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-,(Z)-methyl-2,3-diphenyl-2-butenoate (42443-37-8,42443-38-9) → 2,3-diphenyl-crotonic acid (34317-82-3)

Guidance literature:

With lithium hydroxide monohydrate; In 1,4-dioxane; water; Reflux;

DOI:10.1021/acs.orglett.0c00620

Reference yield: 88.0%

carbon dioxide (124-38-9,18923-20-1) + methylmagnesium bromide (75-16-1) + diphenyl acetylene (501-65-5) → 2,3-diphenyl-crotonic acid (34317-82-3)

Guidance literature:

methylmagnesium bromide; diphenyl acetylene; With nickel(II) bromide 2-methoxyethyl ether complex; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 1h;

carbon dioxide; In tetrahydrofuran; at 25 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature;

Reference yield: 74.0%

1-Phenylprop-1-yne (673-32-5) + carbon dioxide (124-38-9,18923-20-1) + phenylmagnesium bromide (100-58-3) → (Z)-2,3-diphenyl-2-butenoic acid (34317-82-3,60728-09-8,60728-10-1)

Guidance literature:

1-Phenylprop-1-yne; phenylmagnesium bromide; With nickel dichloride; In tetrahydrofuran; toluene; at 60 ℃; for 2h; Schlenk technique; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; toluene; at 20 ℃; for 0.5h; under 760.051 Torr; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01693

upstream raw materials:

opt.-inakt. 3-Hydroxy-2,3-diphenyl-buttersaeure-methylester

acetophenone

carbon dioxide

dimethyl zinc(II)

Downstream raw materials:

1,2-diphenylpropene

acetophenone

benzoic acid

(2R,3R)-2,3-diphenylbutanoic acid