Pyridine, 4-methoxy-3,5-dimethyl-, 1-oxide

Base Information

• Chemical Name: Pyridine, 4-methoxy-3,5-dimethyl-, 1-oxide
• CAS No.: 91219-89-5
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.181
• UNII: XP35GVF6PF
• Mol file: 91219-89-5.mol

Synonyms:91219-89-5;4-Methoxy-3,5-dimethylpyridine 1-Oxide;Pyridine, 4-methoxy-3,5-dimethyl-, 1-oxide;4-methoxy-3,5-dimethyl-1-oxidopyridin-1-ium;XP35GVF6PF;SCHEMBL7951653;QVLHHDZWTFJIPA-UHFFFAOYSA-N;4-Methoxy-3,5-dimethylpyridine1-Oxide;3,5-Dimethyl-4-methoxypyridine N-oxide;3,5-dimethyl-4-methoxy-pyridine-N-oxide;CS-0166419;E74562;4-methoxy-3,5-dimethylpyridine 1-oxide? (Omeprazole Impurity

Chemical Property of Pyridine, 4-methoxy-3,5-dimethyl-, 1-oxide

Chemical Property:

• Melting Point: 70-75°C
• Boiling Point: 314.1±37.0 °C(Predicted)
• PKA: 2.78±0.10(Predicted)
• PSA: 34.69000
• Density: 1.05±0.1 g/cm3(Predicted)
• LogP: 1.74050
• Solubility.: Chloroform, Ethyl Acetate
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 153.078978594
• Heavy Atom Count: 11
• Complexity: 117

Purity/Quality:

98% ^*data from raw suppliers

4-Methoxy-3,5-dimethylpyridine1-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C[N+](=CC(=C1OC)C)[O-]
• Uses: 4-Methoxy-3,5-dimethylpyridine 1-Oxide has been used as a reactant in the preparation of omperazole (O635000), which inhibits gastric secretion and is used as an anttiulcerative.

Technology Process of Pyridine, 4-methoxy-3,5-dimethyl-, 1-oxide

There total 2 articles about Pyridine, 4-methoxy-3,5-dimethyl-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethyl-4-nitropyridine-1-oxide (14248-66-9) + sodium methylate (124-41-4) → 3,5-dimethyl-4-methoxypyridine 1-oxide (91219-89-5)

Guidance literature:

In ethanol; at 60 - 70 ℃; for 15h; Reagent/catalyst; Solvent;

Reference yield:

3,5-Dimethylpyridine N-oxide (3718-65-8) + dichloromethane (75-09-2) + pyrographite (7440-44-0) → 3,5-dimethyl-4-methoxypyridine 1-oxide (91219-89-5)

Guidance literature:

With hydrogenchloride; sodium hydroxide; nitric acid; In methanol; conc. H₂ SO₄; toluene; acetonitrile;

Reference yield:

(NH4)2 S2 O8 + 3,5-dimethyl-4-methoxypyridine 1-oxide (91219-89-5) + dimethyl sulfate (77-78-1) → (4-methoxy-3,5-dimethylpyridin-2-yl)methanol (86604-78-6)

Guidance literature:

With sodium hydroxide; In methanol; water;

upstream raw materials:

3,5-Dimethylpyridine N-oxide

dichloromethane

pyrographite

3,5-dimethyl-4-nitropyridine-1-oxide

Downstream raw materials:

(4-methoxy-3,5-dimethylpyridin-2-yl)methanol