DEHYDRO FELODIPINE-13C4

Base Information

• Chemical Name: DEHYDRO FELODIPINE-13C4
• CAS No.: 96382-71-7
• Molecular Formula: C18H17 Cl2 N O4
• Molecular Weight: 382.243
• Hs Code.: 2933399090
• Mol file: 96382-71-7.mol

Synonyms:3,5-Pyridinedicarboxylicacid, 4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester (9CI);Dehydrofelodipine; H 152/37

Chemical Property of DEHYDRO FELODIPINE-13C4

Chemical Property:

• Vapor Pressure: 4.16E-08mmHg at 25°C
• Melting Point: 70-73C
• Boiling Point: 444.8°Cat760mmHg
• Flash Point: 222.8°C
• PSA: 65.49000
• Density: 1.288g/cm³
• LogP: 4.63550
• Storage Temp.: -20°C Freezer

Purity/Quality:

98%,99%, ^*data from raw suppliers

DehydroFelodipine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The primary metabolite of Felodipine Dehydro Felodipine (Felodipine EP Impurity A) is the primary metabolite of Felodipine.

Technology Process of DEHYDRO FELODIPINE-13C4

There total 5 articles about DEHYDRO FELODIPINE-13C4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate (94739-24-9) + methyl 3-aminocrotonate (14205-39-1) → Dehydrofelodipine (96382-71-7)

Guidance literature:

In ethanol; at 50 - 55 ℃; for 8h; Darkness; Large scale;

Reference yield: 83.1%

ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate (72509-76-3,86189-69-7) → Dehydrofelodipine (96382-71-7)

Guidance literature:

With potassium carbonate; eosin Y bis(tetrabutyl ammonium salt); In methanol; water; at 20 ℃; for 12h; Irradiation; Green chemistry;

DOI:10.1002/cjoc.201400521

Reference yield:

ethyl acetoacetate (141-97-9) + acetoacetic acid methyl ester (105-45-3) + 2,3-dichlorobenzylaldehyde (6334-18-5) → Dehydrofelodipine (96382-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / ethanol / 2 h / 80 °C

2: eosin Y bis(tetrabutyl ammonium salt); potassium carbonate / water; methanol / 12 h / 20 °C / Irradiation; Green chemistry

With ammonium acetate; potassium carbonate; eosin Y bis(tetrabutyl ammonium salt); In methanol; ethanol; water; 1: |Hantzsch Pyridine Synthesis;

DOI:10.1002/cjoc.201400521

upstream raw materials:

ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate

ethyl acetoacetate

acetoacetic acid methyl ester

2,3-dichlorobenzylaldehyde

Refernces

• 1、 -. "A new process for the preparation of felodipine (by machine translation)". Paragraph 0024; 0030; 0031; 0032; 0033. . Retrieved 2018/07/06.
• 2、 Wei, Xiaojing,Wang, Lin,Jia, Wenliang,Du, Shaofu,Wu, Lizhu,Liu, Qiang. "Metal-free-mediated oxidation aromatization of 1,4-dihydropyridines to pyridines using visible light and air". . p. 1245 - 1250. Retrieved 2015/02/05.