Methyl 3-amino-5-methoxyisonicotinate

Base Information

• Chemical Name: Methyl 3-amino-5-methoxyisonicotinate
• CAS No.: 82673-74-3
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.179
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10513616
• Wikidata: Q82373521
• Mol file: 82673-74-3.mol

Synonyms:Methyl 3-amino-5-methoxyisonicotinate;82673-74-3;methyl 3-amino-5-methoxypyridine-4-carboxylate;3-Amino-5-methoxy-isonicotinic acid methyl ester;Methyl3-aMino-5-Methoxyisonicotinate;DTXSID10513616;MFCD20715877;AT28403;SB38894;CS-0340815

Chemical Property of Methyl 3-amino-5-methoxyisonicotinate

Chemical Property:

• PSA: 74.44000
• LogP: 1.04020
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 182.06914219
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-5-methoxy-isonicotinicacidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CN=C1)N)C(=O)OC

Technology Process of Methyl 3-amino-5-methoxyisonicotinate

There total 2 articles about Methyl 3-amino-5-methoxyisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methanol (67-56-1) + 3-amino-5-methoxypyridine-4-carboxylic acid (82673-73-2) → methyl 3-amino-5-methoxypyridine-4-carboxylate (82673-74-3)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Ambient temperature;

Reference yield:

3-Methoxy-5-(pivaloylamino)pyridine-4-carboxylic Acid (77903-35-6) → methyl 3-amino-5-methoxypyridine-4-carboxylate (82673-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / 10 percent hydrochloric acid / 5 h / 90 °C

2: 55 percent / hydrogen chloride / methanol / 2 h / Ambient temperature

With hydrogenchloride; In methanol;

Reference yield: 30.0%

methyl 3-amino-5-methoxypyridine-4-carboxylate (82673-74-3) → methyl 3-methoxy-4-pyridinecarboxylate (59786-32-2)

Guidance literature:

With isopentyl nitrite; In N,N-dimethyl-formamide; at 65 ℃;

upstream raw materials:

methanol

3-amino-5-methoxypyridine-4-carboxylic acid

3-Methoxy-5-(pivaloylamino)pyridine-4-carboxylic Acid

Downstream raw materials:

methyl 3-methoxy-4-pyridinecarboxylate

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