Trt-Lys(Fmoc)-OH

Base Information

• Chemical Name: Trt-Lys(Fmoc)-OH
• CAS No.: 122832-81-9
• Molecular Formula: C₄₀H₃₈N₂O₄
• Molecular Weight: 610.753
• Mol file: 122832-81-9.mol

Synonyms:26454 NALPHA-TRITYL-NGAMMA-FMOC-L-LYSINE;(S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-(trityl-amino)-hexanoic acid;26454 Nα-TRITYL-Nγ-FMOC-L-LYSINE;NAlpha-Trityl-Nε-Fmoc-L-lysine;TRT-L-LYS(FMOC)-OH N-ALPHA-TRITYL-N-EPSILON-(9-FLUORENYLMETHYLOXYCARBONYL)-L-LYSINE;N-alpha-Trityl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine;Trt-Lys(Fmoc)-OH;Trt-K(Fmoc)-OH;Nα-Trityl-Nε-Fmoc-L-lysine;TRT-L-LYS(FMOC)-OH;N-α-Trityl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine;TRT-L-LYS(FMOC)-OH N-α-TRITYL-N-EPSILON-(9-FLUORENYLMETHYLOXYCARBONYL)-L-LYSINE;

Chemical Property of Trt-Lys(Fmoc)-OH

Chemical Property:

• Boiling Point: 789.2±60.0 °C(Predicted)
• PKA: 2.24±0.24(Predicted)
• PSA: 87.66000
• Density: 1.208±0.06 g/cm3(Predicted)
• LogP: 8.51210

Purity/Quality:

99% ^*data from raw suppliers

Trt-D-Lys(Fmoc)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Trt-Lys(Fmoc)-OH

There total 2 articles about Trt-Lys(Fmoc)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-(trityl-amino)-hexanoic acid trityl ester → Trt-K(Fmoc)-OH (122832-81-9)

Guidance literature:

With methanol; In chloroform; N,N-dimethyl-formamide; at 50 ℃; for 1.5h; Yield given;

DOI:10.1055/s-1989-27195

Reference yield:

N-(fluorenyl-9-methoxycarbonyl)-L-lysine (84624-28-2,212140-39-1) → Trt-K(Fmoc)-OH (122832-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / CHCl₃; dimethylformamide / 0.5 h / Ambient temperature

2: MeOH / CHCl₃; dimethylformamide / 1.5 h / 50 °C

With methanol; triethylamine; In chloroform; N,N-dimethyl-formamide;

DOI:10.1055/s-1989-27195

Reference yield:

Fmoc-Leu-OH (35661-60-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Ser(tBu)-OH (71989-33-8) + Fmoc-(tBu)Asp-OH (71989-14-5) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + L-Asn(Trt) (132388-59-1) + Trt-K(Fmoc)-OH (122832-81-9) + 4-<(R,S)-1-<1-(9H-Fluoren-9-yl)methoxycarbonylamino>-(2',4'-dimethoxybenzyl)>phenoxyacetic acid (145069-56-3,126828-35-1) + (R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester (71989-31-6,109425-54-9,144829-96-9,101555-62-8) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) → C143H181N19O28

Guidance literature:

(R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester; With dmap; diisopropyl-carbodiimide; In DCM; N,N-dimethyl-formamide; at 25 ℃; for 2h;

With acetic anhydride; N-ethyl-N,N-diisopropylamine; In DCM; N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; N-Fmoc L-Phe; Fmoc-Ser(tBu)-OH; Fmoc-(tBu)Asp-OH; Fmoc-Lys(tert-butoxycarbonyl); L-Asn(Trt); Trt-K(Fmoc)-OH; 4-<(R,S)-1-<1-(9H-Fluoren-9-yl)methoxycarbonylamino>-(2',4'-dimethoxybenzyl)>phenoxyacetic acid; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Further stages;

DOI:10.1039/c2cc17222d

upstream raw materials:

N-(fluorenyl-9-methoxycarbonyl)-L-lysine