2-Thiophenepentanoic acid, d-oxo-, methyl ester

Base Information

• Chemical Name: 2-Thiophenepentanoic acid, d-oxo-, methyl ester
• CAS No.: 18760-47-9
• Molecular Formula: C10H12O3S
• Molecular Weight: 212.269
• Hs Code.: 2934999090
• Mol file: 18760-47-9.mol

Synonyms:2-Thiophenepentanoic acid, d-oxo-, Methyl ester;Methyl 5-Oxo-5-(2-thienyl)pentanoate;delta-Oxo-2-thiophenepentanoic acid methyl ester;Methyl 5-oxo-5-(thiophen-2-yl)pentanoate

Chemical Property of 2-Thiophenepentanoic acid, d-oxo-, methyl ester

Chemical Property:

• Refractive Index: 1.5377 (589.3 nm 20℃)
• PSA: 71.61000
• LogP: 2.27410
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-oxo-5-(thiophen-2-yl)pentanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenepentanoic acid, d-oxo-, methyl ester

There total 7 articles about 2-Thiophenepentanoic acid, d-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + C18H32OSSn → methyl 5-(2-thienyl)-5-oxopentanoate (18760-47-9)

Guidance literature:

With tetrabutylammomium bromide; In tetrahydrofuran; for 12h; Heating;

DOI:10.1021/jo990062b

Reference yield: 91.0%

methyl 4-(chlorocarbonyl)butyrate (1501-26-4) + thiophen-2-yl magnesium bromide (5713-61-1) → methyl 5-(2-thienyl)-5-oxopentanoate (18760-47-9)

Guidance literature:

With copper(I) bromide; lithium bromide; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1016/0040-4020(96)00805-8

Reference yield: 90.0%

methanol (67-56-1) + 5-oxo-5-thiophen-2-yl-pentanoic acid (22971-62-6) → methyl 5-(2-thienyl)-5-oxopentanoate (18760-47-9)

Guidance literature:

With hydrogenchloride; water; for 5h; Reflux;

DOI:10.1039/b925089a

upstream raw materials:

thiophene

methyl 4-(chlorocarbonyl)butyrate

thiophen-2-yl magnesium bromide

Pentanedioic acid, monomethyl ester

Downstream raw materials:

5-[5-(3-p-Tolyl-propyl)-thiophen-2-yl]-pentanoic acid

1-Morpholin-4-yl-5-[5-(3-p-tolyl-propyl)-thiophen-2-yl]-pentan-1-one

5-[5-(3-p-Tolyl-propyl)-thiophen-2-yl]-1-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-pentan-1-one

methyl 5-(2-thienyl)-5-oxopentanoate p-tosylhydrazone