Ethyl 4-chloro-2-fluorophenylacetate

Base Information

• Chemical Name: Ethyl 4-chloro-2-fluorophenylacetate
• CAS No.: 188424-98-8
• Molecular Formula: C10H10ClFO2
• Molecular Weight: 216.64
• DSSTox Substance ID: DTXSID70403862
• Wikidata: Q82207715
• Mol file: 188424-98-8.mol

Synonyms:188424-98-8;ethyl 4-chloro-2-fluorophenylacetate;ethyl 2-(4-chloro-2-fluorophenyl)acetate;Benzeneacetic acid, 4-chloro-2-fluoro-, ethyl ester;MFCD01570543;Ethyl 2-(4-chloro-2-fluoro-phenyl)acetate;SCHEMBL512637;(4-CHLORO-2-FLUOROPHENYL)ACETIC ACID ETHYL ESTER;DTXSID70403862;UNWCPRLQLHLRLY-UHFFFAOYSA-N;ethyl 4-choro-2-fluorophenylacetate;AKOS015961296;ethyl2-(4-chloro-2-fluorophenyl)acetate;BS-41658;SY073827;CS-0061616;A856772

Chemical Property of Ethyl 4-chloro-2-fluorophenylacetate

Chemical Property:

• Boiling Point: 254.6±25.0 °C(Predicted)
• Density: 1.238±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 216.0353354
• Heavy Atom Count: 14
• Complexity: 199

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(4-chloro-2-fluorophenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1=C(C=C(C=C1)Cl)F

Technology Process of Ethyl 4-chloro-2-fluorophenylacetate

There total 5 articles about Ethyl 4-chloro-2-fluorophenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4-chloro-2-fluorophenyl)acetic acid (194240-75-0) + ethanol (64-17-5) → ethyl 2-(4-chloro-2-fluorophenyl)acetate (188424-98-8)

Guidance literature:

With sulfuric acid; for 12h; Reflux;

Reference yield:

2-(4-chloro-2-fluoro-phenyl)acetonitrile (75279-53-7) → ethyl 2-(4-chloro-2-fluorophenyl)acetate (188424-98-8)

Guidance literature:

In ethanol;

Reference yield:

4-chloro-benzeneacetic acid, ethyl ester (14062-24-9) → Ethyl 4-chloro-α-fluorophenylacetate (74569-27-0) + (4-Chloro-3-fluoro-phenyl)-acetic acid ethyl ester (1256479-12-5) + ethyl 2-(4-chloro-2-fluorophenyl)acetate (188424-98-8) + ethyl 4-chlorophenyl-2,2-difluoroacetate (130754-19-7)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In sulfolane; at 50 ℃; Further byproducts given; electrolysis;

DOI:10.1016/S0022-1139(00)80368-1

upstream raw materials:

4-chloro-benzeneacetic acid, ethyl ester

4-chlorophenylacetic Acid

2-(4-chloro-2-fluoro-phenyl)acetonitrile

2-(4-chloro-2-fluorophenyl)acetic acid

Downstream raw materials:

ethyl (2-fluoro-4-chlorophenyl)malonate

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