1,3-BIS(1-IMIDAZOLYL)PROPANE

Base Information

• Chemical Name: 1,3-BIS(1-IMIDAZOLYL)PROPANE
• CAS No.: 69506-85-0
• Molecular Formula: C9H12N4
• Molecular Weight: 176.221
• Mol file: 69506-85-0.mol

Synonyms:1,3-BIS(1-IMIDAZOLYL)PROPANE

Chemical Property of 1,3-BIS(1-IMIDAZOLYL)PROPANE

Chemical Property:

• Melting Point: 82-84 °C
• Boiling Point: 443.9±28.0 °C(Predicted)
• PKA: 7.18±0.10(Predicted)
• PSA: 35.64000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 1.16990

Purity/Quality:

98.5% ^*data from raw suppliers

1,3-Di(1H-imidazol-1-yl)propane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-BIS(1-IMIDAZOLYL)PROPANE

There total 4 articles about 1,3-BIS(1-IMIDAZOLYL)PROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1H-imidazole (288-32-4) + 1,3-dibromo-propane (109-64-8) → 1-[3-(1H-imidazol-1-yl)propyl]-1H-imidazole (69506-85-0)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.organomet.1c00509

Reference yield: 82.0%

1-methyl-1H-imidazole (616-47-7) + 1,3-dibromo-propane (109-64-8) → 1-[3-(1H-imidazol-1-yl)propyl]-1H-imidazole (69506-85-0)

Guidance literature:

In acetonitrile; at 70 ℃; for 24h;

Reference yield: 70.0%

1H-imidazole (288-32-4) + 1.3-chlorobromopropane (109-70-6) → 1-[3-(1H-imidazol-1-yl)propyl]-1H-imidazole (69506-85-0)

Guidance literature:

1H-imidazole; With potassium hydroxide; In tetrahydrofuran; at 66 ℃; for 1h;

1.3-chlorobromopropane; In tetrahydrofuran; at 60 ℃; for 24h;

DOI:10.1016/j.ica.2016.12.021

upstream raw materials:

1H-imidazole

1,3-dibromo-propane

3-(1H-imidazol-1-yl)propan-1-amine

formaldehyd

Refernces

• 1、 Lalegani, Arash,Khaledi Sardashti, Mohammad,Khalaj, Mehdi,Gajda, Roman,Wo?niak, Krzysztof. "Syntheses and structural characterization of Cu(II) and Mn(II) coordination polymers with the neutral flexible bidentate N-donor ligands". . p. 136 - 144. Retrieved 2017.
• 2、 Dutschke, Patrick D.,Hahn, F. Ekkehardt,Hepp, Alexander,Lübbering, Tobias. "Reactivity of Ruthenium(II) Complexes Bearing Bis-NHC Ligands". supporting information. p. 3775 - 3784. Retrieved 2021/11/17.
• 3、 -. "A amino-containing double-nuclear alkaline ionic liquid and its preparation method and application". Paragraph 0035; 0036; 0037. . Retrieved 2017/09/26.