[2-(4-Bromo-pyrazol-1-yl)-ethyl]-dimethyl-amine

Base Information

• Chemical Name: [2-(4-Bromo-pyrazol-1-yl)-ethyl]-dimethyl-amine
• CAS No.: 847818-54-6
• Molecular Formula: C7H12BrN3
• Molecular Weight: 218.096
• Hs Code.: 2933199090
• Mol file: 847818-54-6.mol

Synonyms:[2-(4-Bromo-pyrazol-1-yl)-ethyl]-dimethyl-amine;2-(4-BroMo-1H-pyrazol-1-yl)-N,N-diMethylethanaMine;4-bromo-N,N-dimethyl-1H-Pyrazole-1-ethan amine;4-Bromo-N,N-dimethyl-pyrazole-1-ethanamine

Chemical Property of [2-(4-Bromo-pyrazol-1-yl)-ethyl]-dimethyl-amine

Chemical Property:

• Vapor Pressure: 0.012mmHg at 25°C
• Boiling Point: 261.348°C at 760 mmHg
• Flash Point: 111.859°C
• PSA: 21.06000
• Density: 1.419g/cm³
• LogP: 1.20720
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-N,N-dimethyl-pyrazole-1-ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-(4-Bromo-pyrazol-1-yl)-ethyl]-dimethyl-amine

There total 3 articles about [2-(4-Bromo-pyrazol-1-yl)-ethyl]-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-bromo-1H-pyrazole (2075-45-8) + 2-(N,N-dimethylamino)ethyl bromide (5459-68-7) → 2-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylethanamine (847818-54-6)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; dimethyl sulfoxide; at 20 ℃;

Reference yield: 86.0%

4-bromo-1H-pyrazole (2075-45-8) + (2-chloroethyl)dimethylamine hydrochloride (4584-46-7) → 2-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylethanamine (847818-54-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

4-bromo-1H-pyrazole (2075-45-8) + dimethyl amine (124-40-3) + 1-Bromo-2-chloroethane (107-04-0) → 2-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylethanamine (847818-54-6)

Guidance literature:

4-bromo-1H-pyrazole; 1-Bromo-2-chloroethane; With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h; Microwave irradiation;

dimethyl amine; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 - 100 ℃; Microwave irradiation;

upstream raw materials:

4-bromo-1H-pyrazole

(2-chloroethyl)dimethylamine hydrochloride

dimethyl amine

1-Bromo-2-chloroethane

Downstream raw materials:

N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-amine

N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-amine

N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)acetamide

Refernces

• 1、 -. "Imidazo[1,2-a]pyridine compound, and preparation method and applications thereof". Paragraph 0110. . Retrieved 2017/08/28.
• 2、 -. "PROTEIN KINASE INHIBITORS". Page/Page column 29. . Retrieved 2013/04/25.