amino-PEG8-t-butyl ester

Base Information

Chemical Name:amino-PEG8-t-butyl ester
CAS No.:756526-06-4
Molecular Formula:C23H47NO10
Molecular Weight:497.627
Hs Code.:2942000090
European Community (EC) Number:856-556-7
Mol file:756526-06-4.mol

Synonyms:amino-PEG8-t-butyl ester;756526-06-4;Amino-PEG8-Boc;H2N-PEG8-CH2CH2COOtBu;Amino-PEG8-COOtBu;tert-Butyl 1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate;NH2-PEG8-CH2CH2COOtBu;MFCD11041142;1-AMINO-3,6,9,12,15,18,21,24-OCTAOXAHEPTACOSAN-27-OIC ACID T-BUTYL ESTER;tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate;SCHEMBL19384768;C23H47NO10;HY-W019799;s10747;BP-21119;BS-17527;SY251208;CS-0031590

Suppliers and Price of amino-PEG8-t-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

purepeg
H2N-PEG8-CH2CH2COOtBu min.97%
250 mg
$ 188.00

Iris Biotech GmbH
H2N-PEG(8)-CO-OtBu
1 g
$ 702.00

Iris Biotech GmbH
H2N-PEG(8)-CO-OtBu
100 mg
$ 391.50

dPEG
Amino-dPEG??-t-butylester
1000 mg
$ 375.00

Crysdot
tert-Butyl1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate 97%
1g
$ 610.00

ChemScene
Amino-PEG8-Boc ≥97.0%
100mg
$ 120.00

ChemScene
Amino-PEG8-Boc ≥97.0%
250mg
$ 199.00

ChemScene
Amino-PEG8-Boc ≥97.0%
1g
$ 420.00

chempep
H2N-PEG8-tBu >=95%
5g
$ 1337.00

chempep
H2N-PEG8-tBu >=95%
1g
$ 511.00

Total 20 raw suppliers

Chemical Property of amino-PEG8-t-butyl ester

Chemical Property:

Boiling Point:544.3±45.0 °C(Predicted)
PKA:8.74±0.10(Predicted)
PSA：126.16000
Density:1.067±0.06 g/cm3(Predicted)
LogP:1.51000
Storage Temp.:2-8°C(protect from light)
Solubility.:Soluble in Water, DMSO, DCM, DMF
XLogP3:-1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:28
Exact Mass:497.31999670
Heavy Atom Count:34
Complexity:435

Purity/Quality:

97% ^*data from raw suppliers

H2N-PEG8-CH2CH2COOtBu min.97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN
Description Amino-PEG8-t-butyl ester is a monodisperse PEG linker containing an amino group with a t-butyl protected carboxyl group.The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses H2N-PEG8-tBu is a cleavable 8-unit PEG-ADC linker for antibody drug conjugate (ADC) synthesis.

Technology Process of amino-PEG8-t-butyl ester

There total 4 articles about amino-PEG8-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345337-28-1
C₃₀H₅₂O₁₃S

: 756526-06-4
tert-Butyl 1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

Guidance literature:: With ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; at 40 ℃; for 24h;

Reference yield:

: 1334177-84-2
tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

: 756526-06-4
tert-Butyl 1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 30 °C

2: ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 24 h / 40 °C

With ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; In dichloromethane;

Reference yield:

: 5117-19-1
octaethylene glycol

: 756526-06-4
tert-Butyl 1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / dichloromethane / 1 h / 20 °C

1.2: 12 h / 20 °C

2.1: triethylamine / dichloromethane / 12 h / 30 °C

3.1: ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 24 h / 40 °C

With ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; sodium; triethylamine; In dichloromethane;