2,4-Dichloro-6-ethoxypyrimidine

Base Information

• Chemical Name: 2,4-Dichloro-6-ethoxypyrimidine
• CAS No.: 858447-32-2
• Molecular Formula: C₆H₆Cl₂N₂O
• Molecular Weight: 193.032
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID40598072
• Wikidata: Q82493788
• Mol file: 858447-32-2.mol

Synonyms:2,4-dichloro-6-ethoxypyrimidine;858447-32-2;2,6-Dichloro-4-ethoxy-pyrimidine;SCHEMBL9432871;DTXSID40598072;AKOS016845335;SB57633;DB-302364;F19672;A849832;J-507151

Chemical Property of 2,4-Dichloro-6-ethoxypyrimidine

Chemical Property:

• PSA: 35.01000
• LogP: 2.18210
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.9857182
• Heavy Atom Count: 11
• Complexity: 125

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-6-ethoxypyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC(=NC(=N1)Cl)Cl

Technology Process of 2,4-Dichloro-6-ethoxypyrimidine

There total 3 articles about 2,4-Dichloro-6-ethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,4,6-trichloropyrimidine (3764-01-0) + ethanol (64-17-5) → 4,6-dichloro-2-ethoxypyrimidine (40758-65-4) + 2,4-dichloro-6-ethoxypyrimidine (858447-32-2) + 4-chloro-2,6-diethoxypyrimidine (93232-55-4)

Guidance literature:

With sodium; at 0 ℃; for 24h;

DOI:10.1021/jm701182y

Reference yield:

2,4,6-trichloropyrimidine (3764-01-0) + sodium ethanolate (141-52-6) → 2,4-dichloro-6-ethoxypyrimidine (858447-32-2)

Guidance literature:

Reference yield:

2,4,6-trichloropyrimidine (3764-01-0) + ethanol (64-17-5) + sodium ethanolate (141-52-6) → 2,4-dichloro-6-ethoxypyrimidine (858447-32-2)

Guidance literature:

at 0 ℃;

upstream raw materials:

2,4,6-trichloropyrimidine

ethanol

sodium ethanolate