2-Methoxy-5-benzyloxypyridine

Base Information

• Chemical Name: 2-Methoxy-5-benzyloxypyridine
• CAS No.: 1083329-15-0
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.252
• Mol file: 1083329-15-0.mol

Synonyms:2-Methoxy-5-benzyloxypyridine;5-(Benzyloxy)-2-Methoxypyridine;Pyridine, 2-methoxy-5-(phenylmethoxy)-

Chemical Property of 2-Methoxy-5-benzyloxypyridine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-5-benzyloxypyridine

There total 1 articles about 2-Methoxy-5-benzyloxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-iodo-2-methoxypyridine (13472-61-2) + benzyl alcohol (100-51-6,185532-71-2) → 5-(benzyloxy)-2-methoxypyridine (1083329-15-0)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; cesium bicarbonate; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo801501e

Reference yield: 100.0%

5-(benzyloxy)-2-methoxypyridine (1083329-15-0) → 6-methoxypyridine-3-ol (51834-97-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.3762/bjoc.9.313

Reference yield:

5-(benzyloxy)-2-methoxypyridine (1083329-15-0) + ethyl iodide (75-03-6) → 5-Benzyloxy-1-ethylpyridin-2(1H)-one (1383746-95-9)

Guidance literature:

In acetonitrile; at 80 ℃; for 28h;

upstream raw materials:

5-iodo-2-methoxypyridine

benzyl alcohol

Downstream raw materials:

5-Benzyloxy-1-ethylpyridin-2(1H)-one

6-methoxypyridine-3-ol