CYCLOPROPYL 3-TRIFLUOROMETHYLPHENYL KETONE

Base Information

• Chemical Name: CYCLOPROPYL 3-TRIFLUOROMETHYLPHENYL KETONE
• CAS No.: 38675-82-0
• Molecular Formula: C11H9F3O
• Molecular Weight: 214.187
• Hs Code.: 2914700090
• Mol file: 38675-82-0.mol

Synonyms:CYCLOPROPYL 3-TRIFLUOROMETHYLPHENYL KETONE;3-(Cyclopropylcarbonyl)benzotrifluoride;cyclopropyl-[3-(trifluoroMethyl)phenyl]Methanone

Chemical Property of CYCLOPROPYL 3-TRIFLUOROMETHYLPHENYL KETONE

Chemical Property:

• Vapor Pressure: 0.0668mmHg at 25°C
• Boiling Point: 230.2°C at 760 mmHg
• Flash Point: 103.5°C
• PSA: 17.07000
• Density: 1.307g/cm³
• LogP: 3.29810

Purity/Quality:

97% ^*data from raw suppliers

3-(Cyclopropylcarbonyl)benzotrifluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOPROPYL 3-TRIFLUOROMETHYLPHENYL KETONE

There total 4 articles about CYCLOPROPYL 3-TRIFLUOROMETHYLPHENYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-bromo-1-trifluoromethylbenzene (401-78-5) + cyclopropropanecarbonitrile (5500-21-0) → cyclopropyl(3-(trifluoromethyl)phenyl)methanone (38675-82-0)

Guidance literature:

3-bromo-1-trifluoromethylbenzene; With n-butyllithium; In hexane; at 0 - 20 ℃; for 4h; Inert atmosphere;

cyclopropropanecarbonitrile; In hexane; at 20 ℃; for 0.166667h; Inert atmosphere;

With toluene-4-sulfonic acid; In hexane; water; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c3cc40643a

Reference yield:

tricyclopropylbismuthane (925430-09-7) + carbon monoxide (201230-82-2) + m-trifluoromethylphenyl iodide (401-81-0) → cyclopropyl(3-(trifluoromethyl)phenyl)methanone (38675-82-0)

Guidance literature:

With (η3-allyl)(N,N'-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene)chloropalladium(II); sodium carbonate; lithium chloride; In N,N-dimethyl-formamide; at 80 ℃; for 16h; under 760.051 Torr; Temperature; Inert atmosphere; Sealed tube;

DOI:10.1055/s-0036-1590832

Reference yield:

cyclopropylmagnesium bromide (23719-80-4) + N-methoxy-N-methyl-3-trifluoromethylbenzamide (116332-62-8) → cyclopropyl(3-(trifluoromethyl)phenyl)methanone (38675-82-0)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

upstream raw materials:

3-bromo-1-trifluoromethylbenzene

cyclopropropanecarbonitrile

3-(Trifluoromethyl)benzoyl chloride

cyclopropylmagnesium bromide

Downstream raw materials:

(m-Trifluormethylphenyl)-cyclopropyl-carbinol

2-Amino-2-cyclopropyl-2-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

9a-(3-(trifluoromethyl)phenyl)-7,8,9,9a-tetrahydrothieno[2,3-g]indolizin-5(4H)-one

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