4-(Benzyloxy)-2-hydroxy-3,5,6-trimethylbenzoic acid methyl ester

Base Information

• Chemical Name: 4-(Benzyloxy)-2-hydroxy-3,5,6-trimethylbenzoic acid methyl ester
• CAS No.: 34874-81-2
• Molecular Formula: C18H20O4
• Molecular Weight: 300.35
• Mol file: 34874-81-2.mol

Synonyms:4-(Benzyloxy)-2-hydroxy-3,5,6-trimethylbenzoic acid methyl ester

Chemical Property of 4-(Benzyloxy)-2-hydroxy-3,5,6-trimethylbenzoic acid methyl ester

Chemical Property:

• Boiling Point: 145 - 150 °C (0.1 mmHg)
• PSA: 55.76000
• LogP: 3.68300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Benzyloxy)-2-hydroxy-3,5,6-trimethylbenzoic acid methyl ester

There total 5 articles about 4-(Benzyloxy)-2-hydroxy-3,5,6-trimethylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2,4-dihydroxy-3,5,6-trimethylbenzoic acid methylester (34874-78-7) + benzyl bromide (100-39-0) → methyl 4-benzyloxy-2-hydroxy-3,5,6-trimethylbenzoate (34874-81-2)

Guidance literature:

With potassium carbonate; In acetone; for 20h; Heating;

Reference yield:

2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester (4707-47-5) → methyl 4-benzyloxy-2-hydroxy-3,5,6-trimethylbenzoate (34874-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / (formylation)

2: Zn, HgCl₂, aq. HCl / ethanol

3: K₂CO₃ / acetone / Heating

With hydrogenchloride; aluminium trichloride; potassium carbonate; mercury dichloride; zinc; In ethanol; acetone;

Reference yield:

atranorin (479-20-9) → methyl 4-benzyloxy-2-hydroxy-3,5,6-trimethylbenzoate (34874-81-2)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) (methylation), (ii) /BRN= 1098229/, NaOMe

2: AlCl₃ / (formylation)

3: Zn, HgCl₂, aq. HCl / ethanol

4: K₂CO₃ / acetone / Heating

With hydrogenchloride; aluminium trichloride; potassium carbonate; mercury dichloride; zinc; In ethanol; acetone;

upstream raw materials:

2,4-dihydroxy-3,5,6-trimethylbenzoic acid methylester

benzyl bromide

2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester

atranorin

Downstream raw materials:

methyl 4-benzyloxy-2-methoxy-3,5,6-trimethylbenzoate

methyl 4-hydroxy-2-methoxy-3,5,6-trimethylbenzoate

methyl 4-O-benzyl-2,2'-di-O-methyleriodermate

methyl 2,4-di-O-benzyl-2'-methyleriodermate