4-Methyl-1H-indole-3-Carbocylic acid methyl ester

Base Information

• Chemical Name: 4-Methyl-1H-indole-3-Carbocylic acid methyl ester
• CAS No.: 858515-77-2
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.214

Synonyms:4-Methyl-1H-indole-3-Carbocylic acid methyl ester

Chemical Property of 4-Methyl-1H-indole-3-Carbocylic acid methyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methyl-1H-indole-3-Carbocylic acid methyl ester

There total 4 articles about 4-Methyl-1H-indole-3-Carbocylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-(9H-fluorene-9-ylidine)-3-methylaniline oxide + propynoic acid methyl ester (922-67-8) → 9-fluorenone (486-25-9,952573-42-1) + methyl 4-methyl-1H-indole-3-carboxylate (858515-77-2) + methyl 6-methyl-1H-indole-3-carboxylate (163083-65-6)

Guidance literature:

N-(9H-fluorene-9-ylidine)-3-methylaniline oxide; propynoic acid methyl ester; In acetonitrile; at 82 ℃; for 4h;

With oxalic acid adsorbed on silica gel; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/s-0035-1560210

Reference yield: 46.0%

N-(3-methylphenyl)hydroxylamine (620-25-7) + propynoic acid methyl ester (922-67-8) → methyl 4-methyl-1H-indole-3-carboxylate (858515-77-2) + methyl 6-methyl-1H-indole-3-carboxylate (163083-65-6)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 0 - 20 ℃; for 1h; Overall yield = 80 percent;

DOI:10.3390/molecules25235595

Reference yield: 6.0%

methanol (67-56-1) + 4-methyl-1H-indole-3-carboxylic acid (858515-65-8) → methyl 4-methyl-1H-indole-3-carboxylate (858515-77-2)

Guidance literature:

With sulfuric acid; at 80 ℃; for 5h;

DOI:10.1021/acs.jmedchem.1c01077

upstream raw materials:

propynoic acid methyl ester

N-(3-methylphenyl)hydroxylamine

1-methyl-3-nitrobenzene

methanol

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