Quinoxaline, 2-(1-methylethyl)- (9CI)

Base Information

• Chemical Name: Quinoxaline, 2-(1-methylethyl)- (9CI)
• CAS No.: 80360-35-6
• Molecular Formula: C11H12N2
• Molecular Weight: 172.22638
• Mol file: 80360-35-6.mol

Synonyms:Quinoxaline, 2-(1-methylethyl)- (9CI)

Chemical Property of Quinoxaline, 2-(1-methylethyl)- (9CI)

Chemical Property:

• Boiling Point: 97 - 103 °C (5 mmHg)
• PSA: 25.78000
• LogP: 2.75320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoxaline, 2-(1-methylethyl)- (9CI)

There total 11 articles about Quinoxaline, 2-(1-methylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloroquinoxaline (1448-87-9) + 2-propylzinc bromide lithium chloride → 2-isopropylquinoxaline (80360-35-6)

Guidance literature:

With C₂₀H₂₉N₂P*BF₄^(1-)*H⁽¹⁺⁾; palladium diacetate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol502230p

Reference yield: 71.0%

2,3-diethynylquinoxaline (91-19-0) + isobutyraldehyde (78-84-2) → 2-isopropylquinoxaline (80360-35-6) + 2-isobutylquinoxaline (25871-19-6)

Guidance literature:

With N-hydroxyphthalimide; cobalt(III) acetylacetonate; cobalt acetylacetonate; In benzonitrile; trifluoroacetic acid; at 70 ℃; for 12h;

DOI:10.1002/jhet.5570400220

Reference yield: 61.0%

2,3-diethynylquinoxaline (91-19-0) + isobutyric Acid (79-31-2) → 2-isopropylquinoxaline (80360-35-6) + 2,3-diisopropylquinoxaline (77611-56-4)

Guidance literature:

With 2-Picolinic acid; ferrous(II) sulfate heptahydrate; sodium bromate; In water; dimethyl sulfoxide; at 20 ℃; for 24h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.9b01439

upstream raw materials:

2,3-diethynylquinoxaline

2-iodo-propane

2-chloroquinoxaline

O-potassio-2,4-dimethyl-3-pentanone

Downstream raw materials:

(S)-2-isopropyl-1,2,3,4-tetrahydroquinoxaline