METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE

Base Information

• Chemical Name: METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE
• CAS No.: 1345847-71-3
• Molecular Formula: C12H12FNO3
• Molecular Weight: 237.231
• Mol file: 1345847-71-3.mol

Synonyms:METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE

Chemical Property of METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE

Chemical Property:

• PSA: 55.40000
• LogP: 1.79040
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ,99% , ^*data from raw suppliers

Methyl1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE

There total 4 articles about METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,1-cyclopropanedicarboxylic acid monomethyl ester (113020-21-6) + 4-fluoroaniline (371-40-4) → methyl 1-((4-fluorophenyl)amidomethyl)cyclopropyl-1-carboxylate (1345847-71-3)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield: 91.3%

dimethyl 1,1-cyclopropanedicarboxylate (6914-71-2,151444-20-1) + 4-fluoroaniline (371-40-4) → methyl 1-((4-fluorophenyl)amidomethyl)cyclopropyl-1-carboxylate (1345847-71-3)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield: 51.8%

methanol (67-56-1) + ((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid (849217-48-7) → methyl 1-((4-fluorophenyl)amidomethyl)cyclopropyl-1-carboxylate (1345847-71-3)

Guidance literature:

With thionyl chloride; at 0 - 65 ℃; for 2h; under 760.051 Torr; Inert atmosphere;

upstream raw materials:

1,1-cyclopropanedicarboxylic acid monomethyl ester

4-fluoroaniline

dimethyl 1,1-cyclopropanedicarboxylate

methanol

Downstream raw materials:

cabozantinib

N'-(3-fluoro-4-hydroxyphenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

N-(4-fluorophenyl)-N'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide

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