Methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carboxylate

Base Information

Chemical Name:Methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carboxylate
CAS No.:1027345-20-5
Molecular Formula:C16H19ClO2
Molecular Weight:278.779
Hs Code.:
Mol file:1027345-20-5.mol

Synonyms:Methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carboxylate;methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carboxylate

Chemical Property:

Boiling Point:357.8±42.0 °C(Predicted)
PSA：26.30000
Density:1.124±0.06 g/cm3(Predicted)
LogP:4.47670

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carboxylate

There total 4 articles about Methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1027345-19-2
methyl 5,5-dimethyl-2-(trifluoromethylsulfonyloxy)cyclohex-1-enecarboxylate

: 1679-18-1
4-Chlorophenylboronic acid

: 1027345-20-5
methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enecarboxylate

Guidance literature:: With cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; at 70 ℃;

Reference yield:

: 50388-51-7
methyl 5,5-dimethyl-2-oxo-cyclohexanecarboxylate

: 1027345-20-5
methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dichloromethane / 0 °C

1.2: -78 - 20 °C

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; 1,2-dimethoxyethane / 70 °C / Inert atmosphere

With sodium hydride; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 4255-62-3
4,4-dimethylcyclohexane-1-one

: 1027345-20-5
methyl 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C

1.2: 60 - 80 °C

2.1: sodium hydride / dichloromethane / 0 °C

2.2: -78 - 20 °C

3.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; 1,2-dimethoxyethane / 70 °C / Inert atmosphere

With sodium hydride; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;