N-Methylamidothiophosphoric acid O,O-dimethyl ester

Base Information

• Chemical Name: N-Methylamidothiophosphoric acid O,O-dimethyl ester
• CAS No.: 31464-99-0
• Molecular Formula: C3H10NO2PS
• Molecular Weight: 155.16
• Mol file: 31464-99-0.mol

Synonyms:N-Methylamidothiophosphoric acid O,O-dimethyl ester

Chemical Property of N-Methylamidothiophosphoric acid O,O-dimethyl ester

Chemical Property:

• Boiling Point: 55 °C(Press: 0.3 Torr)
• PKA: 1.08±0.70(Predicted)
• PSA: 72.39000
• Density: 1.178±0.06 g/cm3(Predicted)
• LogP: 1.76460

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methylamidothiophosphoric acid O,O-dimethyl ester

There total 3 articles about N-Methylamidothiophosphoric acid O,O-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methylamine hydrochloride (593-51-1) + dimethyl chlorothiophosphate (2524-03-0) → N-methyl O,O-dimethyl phosphoramidothioate (31464-99-0)

Guidance literature:

In dichloromethane; at 0 - 35 ℃; for 1h; pH=8.4 - 9.1;

DOI:10.1007/BF03245903

Reference yield: 87.0%

dimethyl chlorothiophosphate (2524-03-0) + methylamine (74-89-5) → N-methyl O,O-dimethyl phosphoramidothioate (31464-99-0)

Guidance literature:

In diethyl ether; for 0.5h;

DOI:10.1021/jo00312a012

Reference yield:

→ N-methyl O,O-dimethyl phosphoramidothioate (31464-99-0)

Guidance literature:

Dimethylphosphoramidothioat, Methylamin;

DOI:10.1021/jf60171a014

upstream raw materials:

dimethyl chlorothiophosphate

methylamine

methylamine hydrochloride

Downstream raw materials:

N,N-dimethyl O,S-dimethyl phosphoramidothioate

N,O,S-Trimethyl-phosphoramidothiolat

dimethyl N-benzoyl-N-methylphosphoramidothionate