1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine
• CAS No.: 908864-98-2
• Molecular Formula: C8H11BrN2
• Molecular Weight: 215.093
• Hs Code.: 2933399090
• Mol file: 908864-98-2.mol

Synonyms:1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine;5-bromo-N,N-dimethyl-3-Pyridinemethan amine;3-Bromo-5-(N,N-dimethylaminomethyl)pyridine

Chemical Property of 1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine

Chemical Property:

• PSA: 16.13000
• LogP: 1.90570
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(5-Bromopyridin-3-yl)-N,N-dimethylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine

There total 8 articles about 1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

5-bromopyridine-3-carbaldehyde (113118-81-3) + N,N-dimethylammonium chloride (506-59-2) → 1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine (908864-98-2)

Guidance literature:

5-bromopyridine-3-carbaldehyde; N,N-dimethylammonium chloride; With triethylamine; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; at 20 ℃;

Reference yield: 92.6%

5-bromopyridine-3-carbaldehyde (113118-81-3) + N-methylmethanamine hydrochloride → 1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine (908864-98-2)

Guidance literature:

5-bromopyridine-3-carbaldehyde; N-methylmethanamine hydrochloride; With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield: 59.0%

3-bromo-5-(chloromethyl)-pyridine hydrochloride (39741-46-3) + dimethyl amine (124-40-3) → 1-(5-bromopyridin-3-yl)-N,N-dimethylmethanamine (908864-98-2)

Guidance literature:

In tetrahydrofuran; methanol; at 0 - 20 ℃; Sealed tube;

upstream raw materials:

5-bromopyridine-3-carbaldehyde

dimethyl amine

3,5-dibromopyridine

3-bromo-5-(chloromethyl)-pyridine hydrochloride

Downstream raw materials:

5-((dimethylamino)methyl)-N-(4-methoxybenzyl)pyridin-3-amine

dimethyl{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]methyl}amine

(5-bromo-3-pyridinyl)methylamine

2-((5-bromopyridin-3-yl)methyl)isoindoline-1,3-dione

Refernces

• 1、 -. "1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS". Page/Page column 34. . Retrieved 2020/01/10.
• 2、 -. "3-(1H-BENZO[D]IMIDAZOL-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF". Paragraph 0629; 0630; 0631; 0632. . Retrieved 2017/02/28.