1,2-BENZENEDICARBOXYLIC ACID,4,5-DIBROMO-,1,2-DIMETHYL ESTER

Base Information

• Chemical Name: 1,2-BENZENEDICARBOXYLIC ACID,4,5-DIBROMO-,1,2-DIMETHYL ESTER
• CAS No.: 859299-66-4
• Molecular Formula: C10H8Br2O4
• Molecular Weight: 351.979
• Mol file: 859299-66-4.mol

Synonyms:1,2-BENZENEDICARBOXYLIC ACID,4,5-DIBROMO-,1,2-DIMETHYL ESTER;Dimethyl 4,5-dibromophthalate;4,5-dibromophthalic acid dimethyl ester

Chemical Property of 1,2-BENZENEDICARBOXYLIC ACID,4,5-DIBROMO-,1,2-DIMETHYL ESTER

Chemical Property:

• Boiling Point: 367.6±37.0 °C(Predicted)
• PSA: 52.60000
• Density: 1.781±0.06 g/cm3(Predicted)
• LogP: 2.78480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

1,2-BENZENEDICARBOXYLICACID,4,5-DIBROMO-,1,2-DIMETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-BENZENEDICARBOXYLIC ACID,4,5-DIBROMO-,1,2-DIMETHYL ESTER

There total 6 articles about 1,2-BENZENEDICARBOXYLIC ACID,4,5-DIBROMO-,1,2-DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

4,5-dibromophthalic acid (24063-28-3) + trimethyl orthoformate (149-73-5) → dimethyl 4,5-dibromo-1,2-benzenedicarboxylate (859299-66-4)

Guidance literature:

With sulfuric acid; In methanol; for 8h; Reflux;

DOI:10.1002/chem.201804655

Reference yield:

methanol (67-56-1) + 4,5-dibromophthalic acid (24063-28-3) → dimethyl 4,5-dibromo-1,2-benzenedicarboxylate (859299-66-4)

Guidance literature:

With hydrogenchloride; at 0 ℃;

Reference yield:

1,2-dibromo-4,5-dimethylbenzene (24932-48-7) → dimethyl 4,5-dibromo-1,2-benzenedicarboxylate (859299-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / water / Autoclave

2: thionyl chloride / 0 °C / Reflux

With thionyl chloride; nitric acid; In water;

DOI:10.1021/acs.joc.0c01235

upstream raw materials:

methanol

4,5-dibromophthalic acid

methyl iodide

trimethyl orthoformate

Downstream raw materials:

3,4-bis(4'-terpyridyl-p-phenyl)-o-dicarbomethoxybenzene

C₁₆H₁₅BrO₄S

C₂₂H₂₂O₄S₂

C₂₀H₁₆N₂S₂

Refernces

• 1、 -. "CEREBLON E3 LIGASE INHIBITORS". Paragraph 0560-0561. . Retrieved 2021/03/05.