24932-48-7

Usage

Uses

Used in Pharmaceutical Industry:
4,5-DIBROMO-O-XYLENE is used as a reagent for the synthesis of Thalidomide (T338850), which is an inhibitor of FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. Thalidomide is also a teratogenic sedative and immunomodulatory agent, primarily used in combination with dexamethasone to treat multiple myeloma.
Used in Photodynamic Therapy:
In the field of photodynamic therapy, 4,5-DIBROMO-O-XYLENE can be utilized in the synthesis of alkylamino zinc(II)phthalocyanines. These compounds have potential applications as photosensitizers, which are crucial components in the treatment process of photodynamic therapy.
Used in Chemical Synthesis:
4,5-DIBROMO-O-XYLENE is also used in the synthesis of 1,2-dibromo-4,5-bis(dibromomethyl)benzene through a reaction with azobisisobutyronitrile. This synthesized compound can have further applications in various chemical processes and industries.

InChI:InChI=1/C8H8Br2/c1-5-3-7(9)8(10)4-6(5)2/h3-4H,1-2H3

Upstream product

• 583-71-1 4-bromo-o-xylene 
• 22364-29-0 2-bromo-4,5-dimethylaniline 
• 95-47-6 o-xylene 
• 7726-95-6 bromine 
• 7553-56-2 iodine 
• 22364-28-9 N-(2-bromo-4,5-dimethylphenyl)acetamide 
• 2198-54-1 N-(3,4-dimethylphenyl)acetamide 
• 75-16-1 methylmagnesium bromide 
• 529502-50-9 1,2-dibromo-4,5-diiodobenzene 

Downstream Products

• 90050-71-8 1,2-dibromo-4,5-dimethyl-3-nitro-benzene 
• 24063-28-3 4,5-dibromophthalic acid 
• 6425-67-8 1,2-dibromo-4,5-bis(bromomethyl)benzene 
• 13209-20-6 α,α,α',α'-tetrabromo-4,5-dibromo-o-xylene 
• 30252-17-6 5,6-Dibrom-2,3-dimethyl-benzylchlorid 
• 30075-68-4 5,6-Dibrom-2,3-dimethyl-1,4-bis(chlormethyl)benzol 
• 36360-43-7 1,2-dicyano-4,5-p-tolylthiobenzene 
• 216433-16-8 1,2-dibromo-4-bromomethyl-5-methylbenzene 
• 95-47-6 o-xylene 
• 95-63-6 1,2,4-Trimethylbenzene 
• 95-93-2 1,2,4,5-tetramethylbenzene 
• 101300-66-7 1,2-bis(trimethylsilyl)-4,5-dimethylbenzene 
• 925668-90-2 2-(2-bromo-4,5-dimethylphenyl)-1-[2-N-(4-methylbenzenesulfonamido)phenyl]ethanone 
• 925668-98-0 2-(2-bromo-4,5-dimethylphenyl)-1-[3-N-(4-methylbenzenesulfonamido)-2-thienyl]ethanone 

Relevant academic research and scientific papers

Peripherally octamethyl zinc(II) phthalocyanines with various axial substituents

A series of zinc(II) phthalocyanine complexes peripherally octa-substituted by methyl groups and with axially ligated N-donor ligands, (Zn(Me)8Pc-L, where L is pyridine (4), 3-methylpyridine (5), 3,4-lutidine (6) and 3,5-lutidine (7)), was synt

Synthesis, characterization and luminescent properties of three-coordinate copper(I) halide complexes containing diphenylamino monodentate phosphine ligand

Three-coordinate copper halide complexes with a bidentate phosphine ligand have received much attention. Here, a series of three-coordinate dinuclear copper halide complexes containing a diphenylamino monodentate phosphine ligand, [CuX(dpnp)]2

Molecular belts. 2. Substrate-directed syntheses of belt-type and cage-type structures

The trebly-diastereoselective synthesis and structural characterization of two macropolycyclic derivatives, which are based npon building blocks incorporating six-membered rings that are both [a,c]- and [a,d]-fused, have been achieved by a Diels-Alder oli

Multisubstituted C2-symmetric ansa -metallocenes bearing nitrogen heterocycles: Influence of substituents on catalytic properties in propylene polymerization at higher temperatures

In this work we systematically studied the effects of modifications of substituents on the performance of the isospecific zirconocene-based catalyst family, Me2Si(2-Alk-4-(N-carbazolyl)Ind)ZrX2 (X = Cl, Me), wherein the progenitor was shown to be particul

High-solubility triaryl carboborate as well as preparation method and application thereof

The invention relates to high-solubility triaryl carboborate as well as a preparation method and application thereof. The structural general formula is shown in the specification. The high-solubilitytriaryl carboborate has the advantages of cheap and easi

Subnaphthalocyanine triimides: Potential three-dimensional solution processable acceptors for organic solar cells

Subnaphthalocyanine triimides (SubNcTIs) as solution processable electron acceptors were designed and synthesized by introducing three electron-withdrawing imide groups to subnaphthalocyanines. Their solubility and crystallinity could be adjusted convenie

Dicyano-substituted 2,3-naphthalimide: Synthesis and optoelectronic properties

Organic semiconductors (OSCs) have been attracted intensive academic and commercial interest due to their intriguing optoelectronic properties and potential applications for electronics. However, the development of n-type OSCs has significantly lagged beh

Subphthalocyanine Triimides: Solution Processable Bowl-Shaped Acceptors for Bulk Heterojunction Solar Cells

Ten subphthalocyanine triimides (SubPcTI) with different substituents at imide sites and B atoms were designed and synthesized. These compounds with low-lying lowest unoccupied molecular orbital energy levels (from -3.91 to -3.98 eV), strong absorption in

Synthesis of triphenylene derivatives by Pd-catalyzed Suzuki coupling/intramolecular C–H activation between arylboronic acids and dibromobiphenyls

An efficient and regioselective synthesis of functionalized triphenylenes via palladium-catalyzed Suzuki-Miyaura coupling and subsequent intramolecular C–H activation between arylboronic acids and dibromobiphenyls was developed. This methodology showed excellent atomic economy and regiospecificity as well as synthetic feasibility of unsymmetrical triphenylenes.

Catalysis with chalcogen bonds: Neutral benzodiselenazole scaffolds with high-precision selenium donors of variable strength

The benzodiselenazoles (BDS) introduced in this report fulfill, for the first time, all the prerequisites for non-covalent high-precision chalcogen-bonding catalysis in the focal point of conformationally immobilized σ holes on strong selenium donors in a neutral scaffold. Rational bite-angle adjustment to the long Se-C bonds was the key for BDS design. For the unprecedented BDS motif, synthesis of 12 analogs from o-xylene, crystal structure, σ hole variation strategies, optoelectronic properties, theoretical and experimental anion binding as well as catalytic activity are reported. Chloride binding increases with the depth of the σ holes down to KD = 11 μM in THF. Catalytic activities follow the same trend and culminate in rate enhancements for transfer hydrogenation of quinolines beyond 100000.