rac Guaifenesin Cyclic Carbonate

Base Information

• Chemical Name: rac Guaifenesin Cyclic Carbonate
• CAS No.: 2049-21-0
• Molecular Formula: C11H12O5
• Molecular Weight: 224.213
• Hs Code.: 2932999099
• Mol file: 2049-21-0.mol

Synonyms:rac Guaifenesin Cyclic Carbonate;4-[(2-Methoxyphenoxy)Methyl]-1,3-dioxolan-2-one 3-(o-Methoxyphenoxy)-1,2-propanediol Cyclic Carbonate;Carbonic Acid Cyclic [(o-Methoxyphenoxy)Methyl]ethylene Ester

Chemical Property of rac Guaifenesin Cyclic Carbonate

Chemical Property:

• PSA: 53.99000
• LogP: 1.60940
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly), Methan

Purity/Quality:

98% ^*data from raw suppliers

rac guaifenesin cyclic carbonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Protected Guaifenesin.

Technology Process of rac Guaifenesin Cyclic Carbonate

There total 6 articles about rac Guaifenesin Cyclic Carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

carbon dioxide (124-38-9,18923-20-1) + 2-(2-methoxy-phenoxymethyl)-oxirane (2210-74-4) → rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one (2049-21-0)

Guidance literature:

With imidazolium based ionic liquid incorporated porous dendritic fibrous nanosilica; at 70 ℃; for 2h; under 7500.75 Torr; Green chemistry;

DOI:10.1007/s10562-020-03135-w

Reference yield: 86.0%

carbon monoxide (201230-82-2) + guaifenesin (93-14-1) → rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one (2049-21-0)

Guidance literature:

With palladium 10% on activated carbon; oxygen; sodium acetate; potassium iodide; In 1,2-dimethoxyethane; at 100 ℃; for 3h; under 10343.2 Torr; Autoclave; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.12.116

Reference yield:

guaifenesin (93-14-1) + carbonic acid dimethyl ester (616-38-6) → rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one (2049-21-0)

Guidance literature:

With dmap; lithium hydroxide; at 80 ℃; for 4h; Reagent/catalyst;

upstream raw materials:

Diethyl carbonate

hydrogenchloride

chloroform

3-(2-methoxyphenoxy)propanediol 2-carbamate

Downstream raw materials:

methocarbamol

3-(2-methoxyphenoxy)propanediol 2-carbamate

Refernces

• 1、 Li, Yue-Dan,Cui, Dong-Xiao,Zhu, Jun-Chao,Huang, Ping,Tian, Zhuang,Jia, Yan-Yan,Wang, Ping-An. "Bifunctional phase-transfer catalysts for fixation of CO2 with epoxides under ambient pressure". supporting information. p. 5231 - 5237. Retrieved 2019/10/11.
• 2、 Salanti, Anika,Zoia, Luca,Orlandi, Marco. "Chemical modifications of lignin for the preparation of macromers containing cyclic carbonates". . p. 4063 - 4072. Retrieved 2016/07/21.