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93-14-1

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Product FOB Price Min.Order Supply Ability Supplier
Guaifenesin
Cas No: 93-14-1
No Data No Data 150 Metric Ton/Month Zhejiang Haizhou Pharmaceutical Co., Ltd. Contact Supplier
Guaiphenesin
Cas No: 93-14-1
No Data 10 Kilogram Metric Ton/Day HANGZHOU CLAKE BIOTECH CO.,LTD Contact Supplier
Guaifenesin Manufacturer/High quality/Best price/In stock
Cas No: 93-14-1
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Purity99% Guaifenesin CAS no 93-14-1 manufacturer/supplier
Cas No: 93-14-1
No Data 1 Gram 100 Kilogram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Guaifenesin CAS:93-14-1 Safe delivery Free of customs clearance
Cas No: 93-14-1
USD $ 1.0-10.0 / Kilogram 1 Kilogram 5000 Kilogram/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
USP standard Guaifenesin CAS 93-14-1 with factory price
Cas No: 93-14-1
USD $ 10.0-65.0 / Kilogram 25 Kilogram 50 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Guaifenesin
Cas No: 93-14-1
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
ISO Factory supply High Purity 99% Guaifenesin powder
Cas No: 93-14-1
USD $ 1.0-3.0 / Gram 10 Gram 5000 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
(2S)-3-(2-methoxyphenoxy)propane-1,2-diol
Cas No: 93-14-1
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
TIANFU-CHEM Guaifenesin 93-14-1
Cas No: 93-14-1
No Data 1 Kilogram 10 Metric Ton/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier

93-14-1 Usage

Uses

Centrally acting muscle relaxant with expectorant properties

Description

Guaifenesin is an oral expectorant drug. The expectorant action of guaifenesin is mediated by stimulation of the gastrointestinal tract. It is a common ingredient in prescription and over-the-counter medications used to treat cough due to colds and minor upper respiratory infections.

References

[1] Peter V. Dicpinigaitis and Yvonne E. Gayle, Effect of Guaifenesin on Cough Reflex Sensitivity, 2003, vol. 124, 2178-2181
[2] Leonid Kagan, Eran Lavy and Ammon Hoffmann, Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model, Pulmonary Pharmacology & Therapeutics, 2009, vol. 22, 260-265

Uses

Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.

Brand name

Mucinex (Adams).

Chemical Properties

White Solid
InChI:InChI=1/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3/t8-/m0/s1

93-14-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1301007)  Guaifenesin  United States Pharmacopeia (USP) Reference Standard 93-14-1 1301007-200MG 4,662.45CNY Detail
Sigma-Aldrich (G0700000)  Guaifenesin  European Pharmacopoeia (EP) Reference Standard 93-14-1 G0700000 1,880.19CNY Detail
Alfa Aesar (A16827)  3-(2-Methoxyphenoxy)-1,2-propanediol, 99+%    93-14-1 1000g 3245.0CNY Detail
Alfa Aesar (A16827)  3-(2-Methoxyphenoxy)-1,2-propanediol, 99+%    93-14-1 250g 995.0CNY Detail
Alfa Aesar (A16827)  3-(2-Methoxyphenoxy)-1,2-propanediol, 99+%    93-14-1 50g 300.0CNY Detail

93-14-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Guaifenesin

1.2 Other means of identification

Product number -
Other names Resyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:93-14-1 SDS

93-14-1Synthetic route

oxiranyl-methanol
556-52-5

oxiranyl-methanol

2-methoxy-phenol
90-05-1

2-methoxy-phenol

A

2-(2-methoxyphenoxy)-1,3-propanediol
14007-09-1

2-(2-methoxyphenoxy)-1,3-propanediol

B

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With calcined hydrotalcite In tetrahydrofuran at 120℃; for 4h; Kinetics; Reagent/catalyst; Temperature; Autoclave;A 5%
B 95%
oxiranyl-methanol
556-52-5

oxiranyl-methanol

2-methoxy-phenol
90-05-1

2-methoxy-phenol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 65 - 70℃; for 12h;90%
With sodium hydroxide at 90 - 95℃;56%
With tetrabutylammomium bromide; potassium carbonate; palladium dichloride In water at 60℃; for 5h;55%
Stage #1: 2-methoxy-phenol With potassium hydroxide at 64.84℃; Inert atmosphere;
Stage #2: oxiranyl-methanol With hydrogenchloride Inert atmosphere;
2-(2-methoxy-phenoxymethyl)-oxirane
2210-74-4

2-(2-methoxy-phenoxymethyl)-oxirane

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With perchloric acid81%
With perchloric acid In water at 80℃;80%
With sulfuric acid; water at 70℃; for 2h;59.1%
2-methoxy-phenol
90-05-1

2-methoxy-phenol

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 210℃; for 0.25h; Microwave irradiation;75%
Stage #1: 2-methoxy-phenol With sodium hydroxide In ethanol; water for 0.5h; Heating;
Stage #2: 3-monochloro-1,2-propanediol In ethanol; water for 8h; Heating;
61%
With sodium hydroxide
3-Amino-1,2-propanediol
616-30-8, 13552-31-3

3-Amino-1,2-propanediol

2-methoxy-phenol
90-05-1

2-methoxy-phenol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
Stage #1: 2-methoxy-phenol With potassium chloride; sodium sulfite at 50℃; for 3h; Reflux;
Stage #2: 3-Amino-1,2-propanediol at 90℃; for 5h; Temperature; Concentration;
72%
4-hydroxymethyl-1,3-dioxolan-2-one
931-40-8

4-hydroxymethyl-1,3-dioxolan-2-one

2-methoxy-phenol
90-05-1

2-methoxy-phenol

A

1,3-bis(2-methoxyphenoxy)propan-2-ol
16929-60-5

1,3-bis(2-methoxyphenoxy)propan-2-ol

B

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 160℃; for 9.5h; Inert atmosphere; Schlenk technique;A 9%
B 64%
sodium 2-methoxyphenolate
13052-77-2

sodium 2-methoxyphenolate

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With ethanol
methocarbamol
532-03-6

methocarbamol

A

3-(2-methoxyphenoxy)propanediol 2-carbamate
10488-39-8

3-(2-methoxyphenoxy)propanediol 2-carbamate

B

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With water at 70℃; Product distribution; Rate constant; further temperatures, pH 8.0-10.0;
methyl bromide
74-83-9

methyl bromide

3-(2-hydroxy-phenoxy)-propane-1,2-diol
19826-87-0

3-(2-hydroxy-phenoxy)-propane-1,2-diol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With potassium carbonate In acetone
2-methoxy-phenol
90-05-1

2-methoxy-phenol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 43 percent / NaOH / 16 h / 80 °C
2: 81 percent / perchloric acid
View Scheme
Multi-step reaction with 2 steps
1: 2.) 50percent aq. NaOH / 1.) 80 deg C, 2.) 4 h
2: 80 percent / 72percent HClO4 / H2O / 80 °C
View Scheme
benzene-1,2-diol
120-80-9

benzene-1,2-diol

1,2-bis<2-(-p-toluenesulfonyloxy)ethoxy>amine

1,2-bis<2-(-p-toluenesulfonyloxy)ethoxy>amine

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOEt / ethanol
2: K2CO3 / acetone
View Scheme
2-methoxy-phenol
90-05-1

2-methoxy-phenol

epichlorohydrin
106-89-8

epichlorohydrin

A

1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol
25772-81-0

1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol

B

1,3-bis(2-methoxyphenoxy)propan-2-ol
16929-60-5

1,3-bis(2-methoxyphenoxy)propan-2-ol

C

guaifenesin
93-14-1

guaifenesin

D

2-(2-methoxy-phenoxymethyl)-oxirane
2210-74-4

2-(2-methoxy-phenoxymethyl)-oxirane

Conditions
ConditionsYield
With sodium hydroxide In toluene at 25 - 30℃; Solvent; Concentration;
2-methoxy-phenol
90-05-1

2-methoxy-phenol

glycerol
56-81-5

glycerol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With potassium carbonate; Diethyl carbonate at 105 - 110℃; for 8h;78 %Spectr.
methocarbamol
532-03-6

methocarbamol

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With ethanol In water at 80℃;
C14H16O7

C14H16O7

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C14H18O7

C14H18O7

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C15H20O7

C15H20O7

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C22H26O10

C22H26O10

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C18H18O10

C18H18O10

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
C22H30O10

C22H30O10

guaifenesin
93-14-1

guaifenesin

Conditions
ConditionsYield
With hydrogenchloride In water at 37℃; pH=0.2; Kinetics; pH-value;
guaifenesin
93-14-1

guaifenesin

tannic acid
5424-20-4

tannic acid

guaifenesin tannate

guaifenesin tannate

Conditions
ConditionsYield
In water at 35 - 50℃; for 1h; Product distribution / selectivity;96.15%
guaifenesin
93-14-1

guaifenesin

2(2-methoxyphenoxy)ethanale
18167-91-4

2(2-methoxyphenoxy)ethanale

Conditions
ConditionsYield
With sodium periodate In water at 10℃; for 1h;95%
chromium(III) chloride hexahydrate

chromium(III) chloride hexahydrate

guaifenesin
93-14-1

guaifenesin

[Cr(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]Cl

[Cr(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]Cl

Conditions
ConditionsYield
In ethanol for 3h; Reflux;94%
guaifenesin
93-14-1

guaifenesin

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3-(2-methoxyphenoxy)-1,2-bis(tert-butyldimethylsiloxy)propane

3-(2-methoxyphenoxy)-1,2-bis(tert-butyldimethylsiloxy)propane

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;94%
guaifenesin
93-14-1

guaifenesin

acetic anhydride
108-24-7

acetic anhydride

(RS)-3-(2-methoxyphenoxy)-propane-1,2-diyl diacetate
92865-65-1

(RS)-3-(2-methoxyphenoxy)-propane-1,2-diyl diacetate

Conditions
ConditionsYield
With pyridine at 4℃; for 4h;90%
2,2-dimethylsuccinic anhydride
17347-61-4

2,2-dimethylsuccinic anhydride

guaifenesin
93-14-1

guaifenesin

C22H30O10

C22H30O10

Conditions
ConditionsYield
Stage #1: guaifenesin With sodium hydride In tetrahydrofuran; mineral oil for 0.5h;
Stage #2: 2,2-dimethylsuccinic anhydride In tetrahydrofuran; mineral oil at 20℃;
90%
guaifenesin
93-14-1

guaifenesin

butyraldehyde
123-72-8

butyraldehyde

4-(2-methoxy-phenoxymethyl)-2-propyl-[1,3]dioxolane

4-(2-methoxy-phenoxymethyl)-2-propyl-[1,3]dioxolane

Conditions
ConditionsYield
With phosphorus pentoxide; silica gel In acetonitrile at 20℃;88%
carbon monoxide
201230-82-2

carbon monoxide

guaifenesin
93-14-1

guaifenesin

rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one
2049-21-0

rac-4-(2-methoxyphenoxymethyl)-[1,3]dioxolan-2-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; oxygen; sodium acetate; potassium iodide In 1,2-dimethoxyethane at 100℃; under 10343.2 Torr; for 3h; Autoclave; Inert atmosphere;86%
guaifenesin
93-14-1

guaifenesin

cyclohexanone
108-94-1

cyclohexanone

2-(2-methoxy-phenoxymethyl)-1,4-dioxa-spiro[4.5]decane

2-(2-methoxy-phenoxymethyl)-1,4-dioxa-spiro[4.5]decane

Conditions
ConditionsYield
With phosphorus pentoxide; silica gel In acetonitrile at 20℃;85%
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

guaifenesin
93-14-1

guaifenesin

glycine
56-40-6

glycine

[Fe(guaifenesin)(2-aminoacetic acid(H-))(Cl)]*3H2O

[Fe(guaifenesin)(2-aminoacetic acid(H-))(Cl)]*3H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;83%
N-methylsulfamoyl chloride
10438-96-7

N-methylsulfamoyl chloride

guaifenesin
93-14-1

guaifenesin

1-[(2-Methoxyphenoxy)methyl]-1,2-ethanediol bis(methylsulfamate) (ester)
136166-31-9

1-[(2-Methoxyphenoxy)methyl]-1,2-ethanediol bis(methylsulfamate) (ester)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 2h; Ambient temperature;82%
guaifenesin
93-14-1

guaifenesin

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose
14215-97-5

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)propane-1,2-diol
664994-56-3

3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)propane-1,2-diol

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 4h;82%
manganese(II) chloride dihydrate

manganese(II) chloride dihydrate

guaifenesin
93-14-1

guaifenesin

[Mn(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]*3H2O

[Mn(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]*3H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;82%
guaifenesin
93-14-1

guaifenesin

1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose
99395-04-7

1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose

3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-xylofuranosyl)propane-1,2-diol
664994-58-5

3-(2-methoxyphenoxy)-1-O-(2,3,5-tri-O-benzoyl-β-D-xylofuranosyl)propane-1,2-diol

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 5h;80%
cadmium(II) chloride dihydrate

cadmium(II) chloride dihydrate

guaifenesin
93-14-1

guaifenesin

[Gd(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]

[Gd(3-(2-methoxyphenoxy)propane-1,2-diol)(Cl)(H2O)2]

Conditions
ConditionsYield
In ethanol for 3h; Reflux;80%
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

guaifenesin
93-14-1

guaifenesin

[Mn(3-(2-methoxyphenoxy)propane-1,2-diol)(H2O)3]Cl2

[Mn(3-(2-methoxyphenoxy)propane-1,2-diol)(H2O)3]Cl2

Conditions
ConditionsYield
In ethanol for 3h; Reflux;80%
guaifenesin
93-14-1

guaifenesin

water
7732-18-5

water

glycine
56-40-6

glycine

platinum(II) chloride

platinum(II) chloride

[Pt(guaifenesin)2(Gly)]Cl*H2O

[Pt(guaifenesin)2(Gly)]Cl*H2O

Conditions
ConditionsYield
In ethanol; N,N-dimethyl-formamide at 70℃; for 1.5h; Reflux;80%
maleic anhydride
108-31-6

maleic anhydride

guaifenesin
93-14-1

guaifenesin

C18H18O10

C18H18O10

Conditions
ConditionsYield
Stage #1: guaifenesin With sodium hydride In tetrahydrofuran; mineral oil for 0.5h;
Stage #2: maleic anhydride In tetrahydrofuran; mineral oil at 20℃;
80%
guaifenesin
93-14-1

guaifenesin

acetic anhydride
108-24-7

acetic anhydride

A

(RS)-3-(2-methoxyphenoxy)-propane-1,2-diyl diacetate
92865-65-1

(RS)-3-(2-methoxyphenoxy)-propane-1,2-diyl diacetate

B

1-O-acetyl-3-(2-methoxyphenoxy)propane-1,2-diol
333381-39-8

1-O-acetyl-3-(2-methoxyphenoxy)propane-1,2-diol

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 3h;A 10%
B 78%
cadmium(II) chloride dihydrate

cadmium(II) chloride dihydrate

guaifenesin
93-14-1

guaifenesin

glycine
56-40-6

glycine

[Cd(guaifenesin)(2-aminoacetic acid(H-))(H2O)]*H2O

[Cd(guaifenesin)(2-aminoacetic acid(H-))(H2O)]*H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;75%
1-benzoylimidazole
10364-94-0

1-benzoylimidazole

guaifenesin
93-14-1

guaifenesin

A

2-hydroxy-3-(2-methoxyphenoxy)propyl benzoate

2-hydroxy-3-(2-methoxyphenoxy)propyl benzoate

B

3-(2-methoxyphenoxy)propane-1,2-diyl dibenzoate

3-(2-methoxyphenoxy)propane-1,2-diyl dibenzoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 8h; regioselective reaction;A 75%
B 15%
guaifenesin
93-14-1

guaifenesin

water
7732-18-5

water

zinc(II) chloride
7646-85-7

zinc(II) chloride

[Zn(glyceryl guaiacolate)(H2O)2]

[Zn(glyceryl guaiacolate)(H2O)2]

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 70℃; pH=8 - 9;74%
guaifenesin
93-14-1

guaifenesin

CVT-4786
13057-65-3

CVT-4786

Conditions
ConditionsYield
Stage #1: guaifenesin With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; toluene at 25℃; for 0.0833333h; pH=6.8;
Stage #2: With sodium hypochlorite; sodium chlorite In aq. phosphate buffer; water; toluene at 50℃; for 24h; pH=6.8;
73%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite In water; acetonitrile at 35℃; aq. phosphate buffer; chemoselective reaction;37.4%
guaifenesin
93-14-1

guaifenesin

A

(2-methoxyphenoxy)acetic acid
1878-85-9

(2-methoxyphenoxy)acetic acid

B

CVT-4786
13057-65-3

CVT-4786

Conditions
ConditionsYield
Stage #1: guaifenesin With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; toluene at 25℃; pH=6.8;
Stage #2: With sodium hypochlorite; sodium chlorite In aq. phosphate buffer; toluene at 50℃; for 24h; chemoselective reaction;
A 10 %Spectr.
B 73%
nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

guaifenesin
93-14-1

guaifenesin

water
7732-18-5

water

[Ni(glyceryl guaiacolate)(H2O)4]*3H2O

[Ni(glyceryl guaiacolate)(H2O)4]*3H2O

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 70℃; pH=8 - 9;73%
2,3-Dimethylmaleic anhydride
766-39-2

2,3-Dimethylmaleic anhydride

guaifenesin
93-14-1

guaifenesin

C22H26O10

C22H26O10

Conditions
ConditionsYield
Stage #1: guaifenesin With sodium hydride In tetrahydrofuran; mineral oil for 0.5h;
Stage #2: 2,3-Dimethylmaleic anhydride In tetrahydrofuran; mineral oil at 20℃;
73%

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