5-(dimethylamino)-2-nitrobenzaldehyde

Base Information

• Chemical Name: 5-(dimethylamino)-2-nitrobenzaldehyde
• CAS No.: 548798-23-8
• Molecular Formula: C9H10N2O3
• Molecular Weight: 194.19
• Mol file: 548798-23-8.mol

Synonyms:5-(dimethylamino)-2-nitrobenzaldehyde

Chemical Property of 5-(dimethylamino)-2-nitrobenzaldehyde

Chemical Property:

• Melting Point: 125-127 °C
• Boiling Point: 365.7±37.0 °C(Predicted)
• PKA: -0.68±0.22(Predicted)
• PSA: 66.13000
• Density: 1.286±0.06 g/cm3(Predicted)
• LogP: 1.99650

Purity/Quality:

99% ^*data from raw suppliers

5-(Dimethylamino)-2-nitrobenzaldehyde ≥97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(dimethylamino)-2-nitrobenzaldehyde

There total 1 articles about 5-(dimethylamino)-2-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-fluoro-2-nitrobenzaldehyde (395-81-3) + dimethyl amine (124-40-3) → 5-(dimethylamino)-2-nitrobenzaldehyde (548798-23-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 105 ℃; for 2h;

DOI:10.1021/jo070433l

Reference yield: 93.0%

5-(dimethylamino)-2-nitrobenzaldehyde (548798-23-8) → 2-amino-5-(N,N-dimethylamino)benzamide (63365-21-9)

Guidance literature:

5-(dimethylamino)-2-nitrobenzaldehyde; With copper diacetate; urea; trifluoroacetic acid; In dimethyl sulfoxide; at 110 ℃;

With hydrazine hydrate; In dimethyl sulfoxide;

DOI:10.1021/acs.joc.1c02343

Reference yield: 85.0%

benzaldehyde (100-52-7) + 5-(dimethylamino)-2-nitrobenzaldehyde (548798-23-8) → 6-(dimethylamino)-2-phenylquinazolin-4(3H)-one

Guidance literature:

5-(dimethylamino)-2-nitrobenzaldehyde; With copper diacetate; urea; trifluoroacetic acid; In dimethyl sulfoxide; at 110 ℃; for 6h;

benzaldehyde; With hydrazine hydrate; In dimethyl sulfoxide;

DOI:10.1021/acs.joc.1c02343

upstream raw materials:

5-fluoro-2-nitrobenzaldehyde

dimethyl amine

Downstream raw materials:

2-amino-5-(dimethylamino)benzaldehyde

2-(4-(N-(2-(1H-benzimidazol-2-yl)-4-(dimethylamino)phenyl)sulfamoyl)phenoxy)acetic acid ethyl ester

2-(4-(N-(4-(dimethylamino)-2-formylphenyl)sulfamoyl)phenoxy)acetic acid ethyl ester

N,N-dimethyl-2,1-benzisoxazole-5-amine

Refernces