Naproxen Methyl Ester

Base Information

• Chemical Name: Naproxen Methyl Ester
• CAS No.: 26159-35-3
• Molecular Formula: C15H16O3
• Molecular Weight: 244.29
• Hs Code.: 2918990090
• European Community (EC) Number: 641-911-9
• UNII: 571OJX4PDN
• DSSTox Substance ID: DTXSID50180780
• Nikkaji Number: J125.832J
• Wikidata: Q27261448
• ChEMBL ID: CHEMBL1823699
• Mol file: 26159-35-3.mol

Synonyms:26159-35-3;(S)-Methyl 2-(6-methoxynaphthalen-2-yl)propanoate;Naproxen Methyl Ester;(S)-Naproxen Methyl Ester;Methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate;(+)-Naproxen Methyl Ester;Naproxen impurity E [EP];UNII-571OJX4PDN;571OJX4PDN;Naproxen sodium impurity E [EP];Methyl (S)-2-(6-Methoxynaphthalen-2-yl)propanoate;2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, methyl ester, (alphaS)-;(S)-Methyl2-(6-methoxynaphthalen-2-yl)propanoate;Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoate (Naproxen Methyl Ester);Naproxen EP Impurity E;Naproxen methyl;Monomethyl derivative of Naproxen;Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoate;Naproxen Imp. E (EP);Naproxen Impurity E;Naproxen methyl derivative;Naproxen Sodium impurity E;(r,s)-naproxen methyl ester;SCHEMBL505819;CHEMBL1823699;DTXSID50180780;MFCD12031841;AKOS026674030;CS-O-15561;AS-72012;NAPROXEN IMPURITY E [EP IMPURITY];Methyl 2-(6-methoxy-2-naphthyl)propanoate #;NAPROXEN SODIUM IMPURITY E [EP IMPURITY];A877350;Q27261448;(S)-Naproxen methyl ester, pharmaceutical impurity standard;2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, methyl ester;2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, methyl ester, ()-;2-NAPHTHALENEACETIC ACID, 6-METHOXY-.ALPHA.-METHYL-, METHYL ESTER, (.ALPHA.S)-;(?S)-6-Methoxy-?-methyl-2-naphthaleneacetic Acid Methyl Ester;Naproxen Imp. E (EP): Methyl (2S)-2-(6-Methoxy-naphthalen-2-yl)propanoate (Naproxen Methyl Ester);RXH

Chemical Property of Naproxen Methyl Ester

Chemical Property:

• Melting Point: 87 °C
• Boiling Point: 358.7±17.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.122±0.06 g/cm3(Predicted)
• LogP: 3.12490
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 244.109944368
• Heavy Atom Count: 18
• Complexity: 290

Purity/Quality:

99%, ^*data from raw suppliers

(S)-NaproxenMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OC
• Isomeric SMILES: C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OC
• Uses: Naproxen (N377520) methyl derivative. Naproxen impurity. Naproxen (N377520) methyl derivative. Naproxen impurity. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) indicated for the treatment of pain, inflammatory conditions such as rheumatoid arthritis, and fever. The drug belongs to the 2-aryl propionic acid family of COX-1 and COX-2 inhibitors.

Technology Process of Naproxen Methyl Ester

There total 8 articles about Naproxen Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

naproxen (23981-80-8) + carbonic acid dimethyl ester (616-38-6) → (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-naproxen methyl ester (81623-44-1) + (S)-naproxen methyl ester (26159-35-3)

Guidance literature:

With Novozym 435; In acetonitrile; at 45 ℃; for 216h; optical yield given as %ee; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.molcatb.2010.01.014

Reference yield:

(R,S) naproxen ethyl ester (31220-35-6,84890-24-4,84890-25-5,37961-57-2) → (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-2-(6-methoxy-2-naphthyl)propionic acid (23979-41-1) + (R)-naproxen methyl ester (81623-44-1) + (S)-naproxen methyl ester (26159-35-3)

Guidance literature:

With Yarrowia lipolytica Lip₂p lipase; In decane; at 20 ℃; for 100h; enantioselective reaction; Kinetics; Enzymatic reaction;

DOI:10.1016/j.tetasy.2017.01.014

Reference yield:

methyl 2-(6-methoxy-2-naphthyl)propionate (30012-51-2) → (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-2-(6-methoxy-2-naphthyl)propionic acid (23979-41-1) + (R)-naproxen methyl ester (81623-44-1) + (S)-naproxen methyl ester (26159-35-3)

Guidance literature:

With phosphate buffer; In 2,2,4-trimethylpentane; at 30 ℃; pH=7.00;

DOI:10.1016/j.jcat.2007.01.021

upstream raw materials:

methanol

(S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid (3aR,5R,6S,6aR)-5-(1,2-dihydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

methyl 2-(6-methoxy-2-naphthyl)propionate

naproxen

Downstream raw materials:

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(S)-2-(1-chloro-2-methoxynaphthalen-6-yl)propanoic acid

2-(6-methoxy-2-naphthyl)-propyl alcohol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 26159-35-3 (S)-α-Methyl-6-methoxy-2-naphthaleneacetic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send