1-(2-BROMO-4-TERT-BUTYLPHENYL)ETHANONE

Base Information

• Chemical Name: 1-(2-BROMO-4-TERT-BUTYLPHENYL)ETHANONE
• CAS No.: 147438-85-5
• Molecular Formula: C₁₂H₁₅BrO
• Molecular Weight: 255.155
• Mol file: 147438-85-5.mol

Synonyms:1-(2-BROMO-4-TERT-BUTYLPHENYL)ETHANONE

Chemical Property of 1-(2-BROMO-4-TERT-BUTYLPHENYL)ETHANONE

Chemical Property:

• Boiling Point: 301.0±35.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.251±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

1-(2-BROMO-4-TERT-BUTYLPHENYL)ETHAN-1-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-BROMO-4-TERT-BUTYLPHENYL)ETHANONE

There total 2 articles about 1-(2-BROMO-4-TERT-BUTYLPHENYL)ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

1-bromo-3-(tertbutyl)benzene (3972-64-3) + acetyl chloride (75-36-5) → 1-(2-bromo-4-(tert-butyl)phenyl)ethan-1-one (147438-85-5)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

bromobenzene (108-86-1,52753-63-6) + Acetyl bromide (506-96-7) + Isobutane (75-28-5,40921-86-6) → acetophenone (98-86-2) + 1-(2-bromo-4-(tert-butyl)phenyl)ethan-1-one (147438-85-5)

Guidance literature:

With aluminium trichloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Br₂, 0 deg C, 10 min, 2.) 0 deg C, 1 h;

DOI:10.1007/BF00702005

Reference yield:

1-(2-bromo-4-(tert-butyl)phenyl)ethan-1-one (147438-85-5) → methyl 2-bromo-4-(tert-butyl)benzoate

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; bromine / water; 1,4-dioxane / 12 h / Cooling with ice

2: sulfuric acid / Reflux

With sulfuric acid; bromine; sodium hydroxide; In 1,4-dioxane; water;

DOI:10.1021/acs.cgd.7b00272

upstream raw materials:

bromobenzene

Acetyl bromide

Isobutane

1-bromo-3-(tertbutyl)benzene