tert-Butyl (2-((2-hydroxyethyl)amino)ethyl)carbamate

Base Information

• Chemical Name: tert-Butyl (2-((2-hydroxyethyl)amino)ethyl)carbamate
• CAS No.: 208577-84-8
• Molecular Formula: C₉H₂₀N₂O₃
• Molecular Weight: 204.269
• European Community (EC) Number: 846-556-5
• DSSTox Substance ID: DTXSID00448807
• Wikidata: Q72448083
• Mol file: 208577-84-8.mol

Synonyms:208577-84-8;tert-Butyl (2-((2-hydroxyethyl)amino)ethyl)carbamate;Tert-butyl N-[2-(2-hydroxyethylamino)ethyl]carbamate;tert-butyl N-{2-[(2-hydroxyethyl)amino]ethyl}carbamate;tert-Butyl n-(2-[(2-hydroxyethyl)amino]ethyl)carbamate;tert-Butyl {2-[(2-hydroxyethyl)amino]ethyl}carbamate;Carbamic acid, [2-[(2-hydroxyethyl)amino]ethyl]-, 1,1-dimethylethyl ester (9CI);SCHEMBL19646831;DTXSID00448807;AKOS015904314;2-(2-Hydroxyethylamino)-N-Boc-ethylamine;FT-0711362;EN300-139917;A814979;tert-Butyl 2-[(2-hydroxyethyl)amino]ethylcarbamate;tert-Butyl(2-((2-hydroxyethyl)amino)ethyl)carbamate;F1906-0422;Z1218077869;Carbamic acid,[2-[(2-hydroxyethyl)amino]ethyl]-,1,1-dimethylethyl ester(9ci)

Chemical Property of tert-Butyl (2-((2-hydroxyethyl)amino)ethyl)carbamate

Chemical Property:

• PSA: 74.08000
• Density: 1.043
• LogP: 0.68830
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 204.14739250
• Heavy Atom Count: 14
• Complexity: 166

Purity/Quality:

97% ^*data from raw suppliers

tert-butylN-{2-[(2-hydroxyethyl)amino]ethyl}carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCCNCCO

Technology Process of tert-Butyl (2-((2-hydroxyethyl)amino)ethyl)carbamate

There total 4 articles about tert-Butyl (2-((2-hydroxyethyl)amino)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate (13139-12-3) + 2-(2-Aminoethylamino)ethanol (111-41-1) → [2-(2-Hydroxy-ethylamino)-ethyl]-carbamic acid tert-butyl ester (208577-84-8)

Guidance literature:

In dichloromethane; 1.) -40 deg C, 3 h, 2.) -40 deg C to r.t., overnight;

DOI:10.1080/00304949809355294

Reference yield:

2-(tert-butoxycarbonylamino)ethyl methanesulfonate (96628-67-0) + ethanolamine (141-43-5) → [2-(2-Hydroxy-ethylamino)-ethyl]-carbamic acid tert-butyl ester (208577-84-8)

Guidance literature:

at 80 ℃; for 8h;

DOI:10.1021/jm030313f

Reference yield:

2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) → [2-(2-Hydroxy-ethylamino)-ethyl]-carbamic acid tert-butyl ester (208577-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 4 h / 0 °C

2: 8 h / 80 °C

With triethylamine; In chloroform;

DOI:10.1021/jm030313f

upstream raw materials:

tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate

2-(2-Aminoethylamino)ethanol

2-(tert-butoxycarbonylamino)ethyl methanesulfonate

ethanolamine

Downstream raw materials:

C₂₅H₃₀N₂O₄

(2-tert-butoxycarbonylaminoethyl)-(2-hydroxyethyl)carbamic acid tert-butyl ester