Methyl 5-iodo-1H-indole-3-carboxylate

Base Information

• Chemical Name: Methyl 5-iodo-1H-indole-3-carboxylate
• CAS No.: 330195-72-7
• Molecular Formula: C₁₀H₈INO₂
• Molecular Weight: 301.084
• Mol file: 330195-72-7.mol

Synonyms:Methyl 5-iodo-1H-indole-3-carboxylate;5-Iodo-1H-indole-3-Carbocylic acid methyl ester;5-Iodo-1H-indole-3-carboxylic acid methyl ester

Chemical Property of Methyl 5-iodo-1H-indole-3-carboxylate

Chemical Property:

• Boiling Point: 408.0±25.0 °C(Predicted)
• PKA: 14.55±0.30(Predicted)
• PSA: 42.09000
• Density: 1.860±0.06 g/cm3(Predicted)
• LogP: 2.55910

Purity/Quality:

97% ^*data from raw suppliers

5-Iodo-1H-indole-3-carboxylicacidmethylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 5-iodo-1H-indole-3-carboxylate

There total 5 articles about Methyl 5-iodo-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(4-iodophenyl)hydroxylamine (14454-14-9) + propynoic acid methyl ester (922-67-8) → methyl 5-iodo-1H-indole-3-carboxylate (330195-72-7)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.3390/molecules25235595

Reference yield: 75.0%

methanol (67-56-1) + 5-iodo-1H-indole (16066-91-4) + trifluoroacetyl chloride (76-02-8) → methyl 5-iodo-1H-indole-3-carboxylate (330195-72-7)

Guidance literature:

5-iodo-1H-indole; trifluoroacetyl chloride; With pyridine; In 1,4-dioxane; at 80 ℃; for 2.5h;

methanol; With sodium hydroxide; at 80 ℃; for 0.5h;

DOI:10.1002/cmdc.201700697

Reference yield: 61.0%

3-methoxycarbonylindole (942-24-5) → methyl 5-iodo-1H-indole-3-carboxylate (330195-72-7)

Guidance literature:

With N-iodo-succinimide; trifluoroacetic acid; In chloroform; at 20 ℃; for 4h; Green chemistry;

upstream raw materials:

3-methoxycarbonylindole

methanol

5-iodo-1H-indole

trifluoroacetyl chloride