6-chloro-2-Methoxynicotinonitrile

Base Information

• Chemical Name: 6-chloro-2-Methoxynicotinonitrile
• CAS No.: 121643-46-7
• Molecular Formula: C7H5ClN2O
• Molecular Weight: 168.583
• Hs Code.: 2933399090
• Mol file: 121643-46-7.mol

Synonyms:6-chloro-2-Methoxynicotinonitrile;6-chloro-2-methoxy-3-Pyridinecarbonitrile

Chemical Property of 6-chloro-2-Methoxynicotinonitrile

Chemical Property:

• Boiling Point: 272.1±35.0 °C(Predicted)
• PKA: -3.30±0.10(Predicted)
• PSA: 45.91000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 1.61528
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-2-methoxynicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-2-Methoxynicotinonitrile

There total 2 articles about 6-chloro-2-Methoxynicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.7%

sodium methylate (124-41-4) + 2,6-dichloro-3-pyridinecarbonitrile (40381-90-6) → 2-chloro-3-cyano-6-methoxypyridine (121643-47-8) + 6-chloro-2-methoxy-3-pyridinecarbonitrile (121643-46-7)

Guidance literature:

In methanol; at 60 ℃; for 12h;

Reference yield: 19.0%

methanol (67-56-1) + sodium methylate (124-41-4) + 2,6-dichloro-3-pyridinecarbonitrile (40381-90-6) → 6-chloro-2-methoxy-3-pyridinecarbonitrile (121643-46-7)

Guidance literature:

at 60 ℃; for 12h;

Reference yield: 49.0%

(4-bromo-3-methylphenyl)carbamic acid tert-butyl ester (654056-82-3) + 6-chloro-2-methoxy-3-pyridinecarbonitrile (121643-46-7) → tert-butyl 4-bromo-3-methylphenyl(5-cyano-6-methoxypyridin-2-yl)carbamate (1213790-37-4)

Guidance literature:

(4-bromo-3-methylphenyl)carbamic acid tert-butyl ester; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere; Cooling with ice;

6-chloro-2-methoxy-3-pyridinecarbonitrile; In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

upstream raw materials:

sodium methylate

2,6-dichloro-3-pyridinecarbonitrile

methanol

Downstream raw materials:

tert-butyl 4-bromo-3-methylphenyl(5-cyano-6-methoxypyridin-2-yl)carbamate

Refernces

• 1、 -. "Neurotrophic factor tyrosine kinase receptor inhibitor". Paragraph 0489; 0491-0493. . Retrieved 2018/05/30.
• 2、 -. "Boron-Containing Small Molecules as Anti-Inflammatory Agents". Paragraph 0800. . Retrieved 2015/11/16.