N,O-Bis(trimethylsilyl)-L-tyrosine trimethylsilyl ester

Base Information

• Chemical Name: N,O-Bis(trimethylsilyl)-L-tyrosine trimethylsilyl ester
• CAS No.: 51220-73-6
• Molecular Formula: C₁₈H₃₅NO₃Si₃
• Molecular Weight: 397.737
• Mol file: 51220-73-6.mol

Synonyms:N,O-Bis(trimethylsilyl)-L-tyrosine trimethylsilyl ester

Chemical Property of N,O-Bis(trimethylsilyl)-L-tyrosine trimethylsilyl ester

Chemical Property:

• PSA: 47.56000
• LogP: 5.00490

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,O-Bis(trimethylsilyl)-L-tyrosine trimethylsilyl ester

There total 3 articles about N,O-Bis(trimethylsilyl)-L-tyrosine trimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → N,O,O'-tris(trimethylsilyl)-(S)-tyrosine (51220-73-6)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Heating;

Reference yield:

N,O-Bis(trimethylsilyl)trifluoroacetamide (25561-30-2) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → N,O,O'-tris(trimethylsilyl)-(S)-tyrosine (51220-73-6) + O,O'-bis(trimethylsilyl)-(S)-tyrosine

Guidance literature:

In acetonitrile; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1016/S0040-4020(01)87943-6

Reference yield:

trimethylsilyl cyanide (7677-24-9) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → N,O,O'-tris(trimethylsilyl)-(S)-tyrosine (51220-73-6)

Guidance literature:

upstream raw materials:

trimethylsilyl cyanide

L-tyrosine

N,O-Bis(trimethylsilyl)trifluoroacetamide

chloro-trimethyl-silane

Downstream raw materials:

H⁽¹⁺⁾Asp(Bzl)-Val-Tyr-OH*Tfa^(1-)

N-<2-(Triphenylphosphonio)isopropyloxycarbonyl>-L-tyrosin-chlorid

L-valyl-L-tyrosine

Trt-Tyr-OH*Et₃N

Refernces

• 1、 Patil, Basanagoud S.,Vasanthakumar, Ganga-Ramu,Suresh Babu, Vommina V.. "Isocyanates of Nα-[(9-fluorenylmethyl)oxy]carbonyl amino acids: Synthesis, isolation, characterization, and application to the efficient synthesis of urea peptidomimetics". . p. 7274 - 7280. Retrieved 2007/10/03.
• 2、 Becu, Fr.,Becu, Chr.,Anteunis, M. J. O.. "SYNTHETIC APPROACHES FOR THYMOPENTIN (TP-5) USING THE "IN SITU" SILYLATION STRATEGY WITH TRIMETHYLSILYL CYANIDE". . p. 15 - 23. Retrieved 2007/10/02.