2,2-Dimethyl-N-(3-trimethylsilanyl-pyridin-2-yl)-propionamide

Base Information

• Chemical Name: 2,2-Dimethyl-N-(3-trimethylsilanyl-pyridin-2-yl)-propionamide
• CAS No.: 86847-63-4
• Molecular Formula: C₁₃H₂₂N₂OSi
• Molecular Weight: 250.416
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90579452
• Wikidata: Q82469975
• Mol file: 86847-63-4.mol

Synonyms:86847-63-4;2,2-Dimethyl-N-(3-trimethylsilanyl-pyridin-2-yl)-propionamide;N-(3-(trimethylsilyl)pyridin-2-yl)pivalamide;2,2-dimethyl-N-(3-trimethylsilylpyridin-2-yl)propanamide;DTXSID90579452;2,2-dimethyl-N-[3-(trimethylsilyl)pyridin-2-yl]propanamide;MFCD05663517;AKOS015841191;AB21840;CS-0456681;A841845;2,2-dimethyl-N-(3-trimethylsilyl-2-pyridinyl)propanamide;2,2-Dimethyl-N-(3-trimethylsilanylpyridin-2-yl)propionamide;2,2-Methyl-N-(3-trimethylsilanyl-pyridin-2-yl)-propionamide;2,2-Dimethyl-N-(3-trimethylsilanyl-pyridin-2-yl)-propionamide, AldrichCPR

Chemical Property of 2,2-Dimethyl-N-(3-trimethylsilanyl-pyridin-2-yl)-propionamide

Chemical Property:

• Vapor Pressure: 7.9E-06mmHg at 25°C
• Melting Point: 101.4-101.5°C
• Boiling Point: 375.2°C at 760 mmHg
• Flash Point: 180.7°C
• PSA: 41.99000
• Density: 0.98g/cm³
• LogP: 2.68440
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 250.150139864
• Heavy Atom Count: 17
• Complexity: 278

Purity/Quality:

97% ^*data from raw suppliers

2,2-Dimethyl-n-(3-trimethylsilanyl-pyridin-2-yl)-propionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C(=O)NC1=C(C=CC=N1)[Si](C)(C)C

Technology Process of 2,2-Dimethyl-N-(3-trimethylsilanyl-pyridin-2-yl)-propionamide

There total 3 articles about 2,2-Dimethyl-N-(3-trimethylsilanyl-pyridin-2-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminopyridine (504-29-0) → 2,2-Dimethyl-N-<3-(trimethylsilyl)-2-pyridinyl>propanamide (86847-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: 1) n-BuLi / THF, hexane, 1) 0 degC, 4h, 2) -78 degC to room temp.

With n-butyllithium; triethylamine; In dichloromethane;

DOI:10.1021/jo00168a007

Reference yield:

pivaloyl chloride (3282-30-2) → 2,2-Dimethyl-N-<3-(trimethylsilyl)-2-pyridinyl>propanamide (86847-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: 1) n-BuLi / THF, hexane, 1) 0 degC, 4h, 2) -78 degC to room temp.

With n-butyllithium; triethylamine; In dichloromethane;

DOI:10.1021/jo00168a007

Reference yield:

chloro-trimethyl-silane (75-77-4) + 2-(pivaloylamino)pyridine (86847-59-8) → 2,2-Dimethyl-N-<3-(trimethylsilyl)-2-pyridinyl>propanamide (86847-63-4)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; THF, hexane, 1) 0 degC, 4h, 2) -78 degC to room temp.;

DOI:10.1021/jo00168a007

upstream raw materials:

chloro-trimethyl-silane

2-(pivaloylamino)pyridine

2-aminopyridine

pivaloyl chloride