1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole

Base Information

• Chemical Name: 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole
• CAS No.: 1227210-31-2
• Molecular Formula: C₆H₇Br₂N₃O₂
• Molecular Weight: 0
• Mol file: 1227210-31-2.mol

Synonyms:1H-Pyrazole, 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-;1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole

Chemical Property of 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole

There total 3 articles about 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-yl)methanol (1227210-30-1) → 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole (1227210-31-2)

Guidance literature:

With phosphorus tribromide; In chloroform; for 2h; Reflux;

Reference yield: 67.0%

ethylene dibromide (106-93-4) + 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (181585-93-3) → 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole (1227210-31-2)

Guidance literature:

ethylene dibromide; 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester; With potassium carbonate; In acetone; for 2h; Reflux;

With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 2h;

With phosphorus tribromide; In chloroform; at 20 ℃; for 2h;

Reference yield:

methyl 1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-carboxylate (1360057-00-6) → 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole (1227210-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

2.1: phosphorus tribromide / chloroform / 0 - 20 °C

2.2: pH 8.5

With lithium borohydride; phosphorus tribromide; In tetrahydrofuran; chloroform;

upstream raw materials:

(1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-yl)methanol

methyl 1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-carboxylate

ethylene dibromide

5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

Downstream raw materials:

5-methyl-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine

2-nitro-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine

1-(2-amino-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)ethanone

5-cyclopropyl-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine