1-Ethyl-1H-indole-2-carbaldehyde

Base Information

• Chemical Name: 1-Ethyl-1H-indole-2-carbaldehyde
• CAS No.: 40913-43-7
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00546872
• Wikidata: Q82424807
• Mol file: 40913-43-7.mol

Synonyms:1-Ethyl-1H-indole-2-carbaldehyde;40913-43-7;1-ETHYLINDOLE-2-CARBALDEHYDE;SCHEMBL4784169;DTXSID00546872;1-ethyl-1h-indole-2-carboxaldehyde;MFCD11877851;AKOS022173359;BS-17248;CS-0054224;F19717

Chemical Property of 1-Ethyl-1H-indole-2-carbaldehyde

Chemical Property:

• PSA: 22.00000
• LogP: 2.47370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 193

Purity/Quality:

97% ^*data from raw suppliers

1-ethyl-1H-indole-2-carbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C2=CC=CC=C2C=C1C=O

Technology Process of 1-Ethyl-1H-indole-2-carbaldehyde

There total 12 articles about 1-Ethyl-1H-indole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1H-indol-2-ylcarboxaldehyde (19005-93-7) + ethyl iodide (75-03-6) → 1-ethyl-1H-indole-2-carbaldehyde (40913-43-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 4h;

Reference yield: 73.0%

N-Ethylindole (10604-59-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-ethyl-1H-indole-2-carbaldehyde (40913-43-7)

Guidance literature:

N-Ethylindole; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 25 ℃; for 1.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

Reference yield: 57.9%

1H-indol-2-ylcarboxaldehyde (19005-93-7) + ethyl bromide (74-96-4) → 1-ethyl-1H-indole-2-carbaldehyde (40913-43-7)

Guidance literature:

1H-indol-2-ylcarboxaldehyde; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h; Inert atmosphere;

ethyl bromide; In dimethyl sulfoxide; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

1-methyl-1H-indole-2-carboxaldehyde

methyl iodide

N-Ethylindole

N,N-dimethyl-formamide

Downstream raw materials:

4-chloro-N-(1-(1-ethyl-1H-indol-2-yl)ethyl)-benzenesulfonamide

3-fluoro-1-ethyl-1H-indole-2-carbaldehyde

9-ethyl-2-p-tolyl-9H-carbazole

9-ethyl-2-(4-methoxyphenyl)-9H-carbazole