tert-butyl 4-(3-(1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yloxy)phenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-(1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yloxy)phenyl)piperazine-1-carboxylate
CAS No.:1380754-72-2
Molecular Formula:C₃₅H₄₀ClN₅O₆
Molecular Weight:662.185
Hs Code.:
Mol file:1380754-72-2.mol

tert-butyl 4-(3-(1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yloxy)phenyl)piperazine-1-carboxylate

Synonyms:tert-butyl 4-(3-(1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yloxy)phenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-(1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yloxy)phenyl)piperazine-1-carboxylate

Chemical Property:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of tert-butyl 4-(3-(1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yloxy)phenyl)piperazine-1-carboxylate

There total 12 articles about tert-butyl 4-(3-(1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yloxy)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1014645-87-4
methyl 4-(1-aminocyclopropyl)benzoate hydrochloride

: 1380753-90-1
2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid

: 1380754-72-2
tert-butyl 4-(3-((1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yl)oxy)phenyl)piperazine-1-carboxylate

Guidance literature:: 2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid; With 1-hydroxy-1H-benzotriazol hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

methyl 4-(1-aminocyclopropyl)benzoate hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

Reference yield:

: 345965-52-8
1-(4-bromophenyl)cyclopropanecarboxylic acid

: 1380754-72-2
tert-butyl 4-(3-((1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yl)oxy)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 5 h / Molecular sieve; Reflux

2.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr

3.1: hydrogenchloride / ethyl acetate / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 0.67 h / 20 °C

4.2: 0.67 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; In methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 360773-84-8
tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

: 1380754-72-2
tert-butyl 4-(3-((1-(5-chloro-3-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)pyridin-2-yl)azetidin-3-yl)oxy)phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide; methanol / 48 h / 80 °C / 30003 Torr

2.1: hydrogenchloride / ethyl acetate / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / N,N-dimethyl-formamide / 0.67 h / 20 °C

3.2: 0.67 h / 20 °C

With hydrogenchloride; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In methanol; ethyl acetate; N,N-dimethyl-formamide;