2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid

Base Information

Chemical Name:2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid
CAS No.:1380753-90-1
Molecular Formula:C₂₄H₂₉ClN₄O₅
Molecular Weight:488.971
Hs Code.:

Synonyms:2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid

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Chemical Property of 2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid

Chemical Property:

Boiling Point:674.3±55.0 °C(Predicted)
Density:1.343±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid

There total 5 articles about 2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 198627-86-0
1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate

: 1380753-13-8
methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate

: 1380753-90-1
2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid

Guidance literature:: 1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate; In N,N-dimethyl-formamide; at 120 ℃; for 21h;

With sodium hydroxide; In N,N-dimethyl-formamide; at 20 - 120 ℃; for 1h;

Reference yield:

: 59817-32-2
3-(piperazin-1-yl)phenol

: 1380753-90-1
2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / water; tetrahydrofuran / 1 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.2: 21 h / 120 °C

2.3: 1 h / 20 - 120 °C

With potassium carbonate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1380753-90-1
2-(3-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenoxy)azetidin-1-yl)-5-chloronicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / water; tetrahydrofuran / 1 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.2: 21 h / 120 °C

2.3: 1 h / 20 - 120 °C

With potassium carbonate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;