4-BroMo-2-(diMethylaMino)pyridine

Base Information

• Chemical Name: 4-BroMo-2-(diMethylaMino)pyridine
• CAS No.: 946000-27-7
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.066
• Hs Code.: 2933399090
• Mol file: 946000-27-7.mol

Synonyms:4-BroMo-2-(diMethylaMino)pyridine;4-broMo-N,N-diMethylpyridin-2-aMine;(4-BroMo-pyridin-2-yl)-diMethyl-aMine

Chemical Property of 4-BroMo-2-(diMethylaMino)pyridine

Chemical Property:

• Boiling Point: 278.4±20.0 °C(Predicted)
• PKA: 6.76±0.10(Predicted)
• PSA: 16.13000
• Density: 1.469±0.06 g/cm3(Predicted)
• LogP: 1.91010
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-bromo-N,N-dimethylpyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-2-(diMethylaMino)pyridine

There total 3 articles about 4-BroMo-2-(diMethylaMino)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-4-bromopyridine (84249-14-9) + methyl iodide (74-88-4) → 4-bromo-N,N-dimethylpyridine-2-amine (946000-27-7)

Guidance literature:

2-amino-4-bromopyridine; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.166667h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 47.0%

2-amino-4-bromopyridine (84249-14-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 4-bromo-N,N-dimethylpyridine-2-amine (946000-27-7)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In water; acetonitrile; at 20 ℃;

Reference yield: 32.0%

4-bromo-2-fluoropyridine (128071-98-7) + dimethyl amine (124-40-3) → 4-bromo-N,N-dimethylpyridine-2-amine (946000-27-7)

Guidance literature:

In tetrahydrofuran; at 100 ℃; for 2h; Microwave irradiation;

upstream raw materials:

2-amino-4-bromopyridine

methyl iodide

formaldehyd

4-bromo-2-fluoropyridine

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND USES THEREOF". Paragraph 0870-0872. . Retrieved 2019/04/25.
• 2、 -. "THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION". Page/Page column 122-123. . Retrieved 2011/06/26.