2-((Dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride

Base Information

• Chemical Name: 2-((Dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride
• CAS No.: 16931-84-3
• Molecular Formula: C₁₂H₁₅NO*ClH
• Molecular Weight: 225.718
• European Community (EC) Number: 605-550-0
• NSC Number: 26626
• ChEMBL ID: CHEMBL3337638
• Mol file: 16931-84-3.mol

Synonyms:ter14687;16931-84-3;2-((Dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride;CHEMBL3337638;2-[(dimethylamino)methyl]-2,3-dihydroinden-1-one;hydrochloride;1H-Inden-1-one, 2,3-dihydro-2-((dimethylamino)methyl)-, hydrochloride;C12H15NO.ClH;SCHEMBL2124625;NSC26626;BDBM50497530;NSC 26626;NSC-26626;LS-81821;FT-0756384;J-010525;2,3-dihydro-2-(N,N-dimethylaminomethyl)-1H-inden-1-one hydrochloride

Chemical Property of 2-((Dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride

Chemical Property:

• Vapor Pressure: 0.00273mmHg at 25°C
• Boiling Point: 285.9°Cat760mmHg
• Flash Point: 101.6°C
• PSA: 20.31000
• Density: 1.073g/cm³
• LogP: 2.40520
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 225.0920418
• Heavy Atom Count: 15
• Complexity: 224

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC1CC2=CC=CC=C2C1=O.Cl

Technology Process of 2-((Dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride

There total 3 articles about 2-((Dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N-dimethyl(methylene)ammonium chloride (30354-18-8) + inden-1-one (83-33-0) → 2-((dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride (16931-84-3)

Guidance literature:

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) + inden-1-one (83-33-0) → 2-((dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride (16931-84-3)

Guidance literature:

With hydrogenchloride; In ethanol; for 24h; Heating;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + inden-1-one (83-33-0) + dimethyl amine (124-40-3) → 2-((dimethylamino)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride (16931-84-3)

Guidance literature:

dimethyl amine; With hydrogenchloride; In water; Cooling with ice;

formaldehyd; inden-1-one; In water; at 90 ℃; for 3h; Inert atmosphere;

upstream raw materials:

formaldehyd

N,N-dimethylammonium chloride

inden-1-one

N,N-dimethyl(methylene)ammonium chloride

Downstream raw materials:

2-[3-Oxo-3-phenyl-2-(toluene-4-sulfonyl)-propyl]-indan-1-one

2-Amino-5H-indeno<1,2-b>pyrid-3-yl-phenylketon

cis-N,N-dimethyl-2,3-dihydro-1-(4-methoxyphenoxy)indene-2-methanamine oxalate

trans-N,N-dimethyl-2,3-dihydro-1-(4-methoxyphenoxy)indene-2-methanamine oxalate