4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide

Base Information

• Chemical Name: 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide
• CAS No.: 1350450-66-6
• Molecular Formula: C₁₆H₂₀N₂O₆
• Molecular Weight: 336.345
• Mol file: 1350450-66-6.mol

Synonyms:4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide

Chemical Property of 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide

There total 6 articles about 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,5-dioxopyrrolidin-1-yl 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoate (1375413-67-4) + Propargylamine (2450-71-7) → 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide (1350450-66-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Darkness; Inert atmosphere;

Reference yield:

4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid (175281-76-2) → 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide (1350450-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere; Darkness

2: triethylamine / N,N-dimethyl-formamide / 20 °C / Darkness; Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

ethyl 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butanoate (1031702-80-3) → 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-N-(prop-2-yn-1-yl)butanamide (1350450-66-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol

2: water / tetrahydrofuran; methanol / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

4: 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

2,5-dioxopyrrolidin-1-yl 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoate

Propargylamine

4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid

ethyl 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butanoate

Downstream raw materials:

1-(5-methoxy-2-nitro-4-(4-oxo-4-(prop-2-yn-1-ylamino)butoxy)phenyl)ethyl (4-nitrophenyl)carbonate