Dichloro(N,N-dimethylethylenediammine)platinum(II)

Base Information

• Chemical Name: Dichloro(N,N-dimethylethylenediammine)platinum(II)
• CAS No.: 41575-66-0
• Molecular Formula: C4H12Cl2N2Pt
• Molecular Weight: 354.139
• DSSTox Substance ID: DTXSID10961815
• Mol file: 41575-66-0.mol

Synonyms:Dichloro(N,N-dimethylethylenediammine)platinum(II);Platinum (II), dichloro(N,N-dimethylethylenediammine)-;41575-66-0;DTXSID10961815;LS-117730;Platinum(2+) chloride--N~1~,N~1~-dimethylethane-1,2-diamine (1/2/1);Platinum, dichloro(N,N-dimethyl-1,2-ethanediamine-N,N')-, (SP-4-3)-

Chemical Property of Dichloro(N,N-dimethylethylenediammine)platinum(II)

Chemical Property:

• Vapor Pressure: 49.3mmHg at 25°C
• Boiling Point: 93.5°C at 760 mmHg
• Flash Point: 23.9°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 353.002548
• Heavy Atom Count: 9
• Complexity: 26.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCN.[Cl-].[Cl-].[Pt+2]

Technology Process of Dichloro(N,N-dimethylethylenediammine)platinum(II)

There total 7 articles about Dichloro(N,N-dimethylethylenediammine)platinum(II) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

cis-(N,N-dimethyl-ethylenediamine)diiodoplatinum(II) (104034-36-8) + sodium chloride (7647-14-5) → (SP-4-3)-dichlorido(N,N-dimethyl-ethane-1,2-diamine)platinum(II) (41575-66-0)

Guidance literature:

With AgNO₃; In water; byproducts: AgI; Pt-complex was suspended in water, AgNO3 in H2O was added, stirred for 2h at 50°C, filtered, NaCl in H2O was added, stirred for 30 min a t 50°C, cooled in refrigerator for 2 ds; elem. anal.;

DOI:10.1016/S0020-1693(02)01058-7

Reference yield: 59.0%

potassium tetrachloroplatinate(II) (10025-99-7) + N,N-dimethylethylenediamine (108-00-9) → (SP-4-3)-dichlorido(N,N-dimethyl-ethane-1,2-diamine)platinum(II) (41575-66-0)

Guidance literature:

In hydrogenchloride; water; (CH3)2NCH2CH2NH2 in 0.1M HCl was added dropwise with stirring to a hot soln. of Pt-complex in H2O, stirring for 10 min; refrigerated overnight, filtered, washed (H2O), dried in vacuo;

Reference yield: 50.0%

potassium tetrachloroplatinate(II) (10025-99-7) + tetrammineplatinum(II) chloride + N,N-dimethylethylenediamine (108-00-9) → magnus green salt + (SP-4-3)-dichlorido(N,N-dimethyl-ethane-1,2-diamine)platinum(II) (41575-66-0) + [Pt(N,N-dimethylethylenediamine)2][PtCl4]

Guidance literature:

In water; K2PtCl4 dissolved in boiling water; cooled; ligand (10% excess) added; after 1 h ppt. filtered; recrystd. (hot water contg. some HCl); filtrateconcd. on rotary evaporator; Pt(NH3)4Cl2 added; mixt. heated with stirr ing; Pt(NH3)4PtCl4 collected on filter; ppt. was obtained from filtrate;washed (aq. HCl, EtOH); elem. anal.;

DOI:10.1134/S0036023608120061

upstream raw materials:

cis-(N,N-dimethyl-ethylenediamine)diiodoplatinum(II)

sodium chloride

potassium tetrachloroplatinate(II)

N,N-dimethylethylenediamine

Downstream raw materials:

carbon dioxide

trans-dichlorobis(pyridine)platinum(II)

thallium chloride

b-chloro-c(N),d(N')-{N,N-dimethyl-N'-(2,3,5,6-tetrafluorophenyl)ethane-1,2-diaminato^(1-)}-a-pyridineplatinum(II)

Refernces

• 1、 Arendse, Malcolm J.,Anderson, Gordon K.,Majola, Raquel N.,Rath, Nigam P.. "Synthesis and reactions of platinum(IV) complexes with sodium ascorbate". . p. 65 - 69. Retrieved 2002.
• 2、 Berners-Price, Susan J.,Frey, Urban,Ranford, John D.,Sadler, Peter J.. "Stereospecific hydrogen-bonding in mononucleotide adducts of platinum anticancer complexes in aqueous solution". . p. 8649 - 8659. Retrieved 2007/10/02.