benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate

Base Information

Chemical Name:benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate
CAS No.:1402585-48-1
Molecular Formula:C₂₅H₃₁FO₃Si
Molecular Weight:426.603
Hs Code.:

Synonyms:benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate

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Chemical Property of benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate

Chemical Property:

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Technology Process of benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate

There total 7 articles about benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402585-47-0
tert-butyl (1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropoxy)dimethylsilane

: 64473-02-5
2-bromoprop-2-enoic acid benzyl ester

: 1402585-48-1
benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1250254-02-4
1-(4-bromo-2-fluorophenyl)cyclopropanol

: 1402585-48-1
benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 3 h / 0 °C

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 - 100 °C / Inert atmosphere

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; caesium carbonate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 112704-79-7
2-fluoro-4-bromobenzoic acid

: 1402585-48-1
benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 12.25 h / 0 - 23 °C

2.1: titanium(IV) isopropylate / diethyl ether / 2.25 h / -78 °C

2.2: 16 h / -78 - 23 °C

3.1: 1H-imidazole / dichloromethane / 3 h / 0 °C

4.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 - 100 °C / Inert atmosphere

With 1H-imidazole; titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; potassium acetate; caesium carbonate; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;