3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester

Base Information

• Chemical Name: 3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester
• CAS No.: 1141681-59-5
• Molecular Formula: C₃₉H₄₅N₃O₈
• Molecular Weight: 683.802
• Mol file: 1141681-59-5.mol

Synonyms:3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester

Chemical Property of 3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester

There total 1 articles about 3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

cyclobutanone (1191-95-3) + Z-Asp(OBzl)-OH (3479-47-8) + 2,4-Dimethoxybenzylamine (20781-20-8) + 1-isocyanocyclohexene (1121-57-9) → 3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester (1141681-59-5)

Guidance literature:

In methanol; pentane; at 20 ℃;

DOI:10.1021/jo802170k

Reference yield: 65.0%

methanol (67-56-1) + 3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester (1141681-59-5) → 1-(3-benzyloxycarbonyl-2-benzyloxycarbonylaminopropionylamino)cyclobutanecarboxylic acid methyl ester (1141681-61-9)

Guidance literature:

3-benzyloxycarbonylamino-N-[1-(cyclohex-1-enylcarbamoyl)-cyclobutyl]-N-(2,4-dimethoxybenzyl)succinamic acid benzyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

methanol; With pyridine; at 20 ℃; for 1h;

DOI:10.1021/jo802170k

upstream raw materials:

cyclobutanone

Z-Asp(OBzl)-OH

2,4-Dimethoxybenzylamine

1-isocyanocyclohexene

Downstream raw materials:

1-(3-benzyloxycarbonyl-2-benzyloxycarbonylaminopropionylamino)cyclobutanecarboxylic acid methyl ester